Product image of Noradrenaline Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline Kabi (Noradrenaline Tartrate)

Norepinephrine tartrate, the active ingredient in Noradrenaline Kabi, is a sympathomimetic presented as a sterile intravenous solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in patients with severe hypotension, septic shock, cardiogenic shock, or cardiac arrest.
GNH India supplies Noradrenaline Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

Noradrenaline Kabi is a sympathomimetic vasopressor used in critical‑care settings to support circulatory function.

  • Hypotension: restores adequate arterial pressure and organ perfusion.
  • Septic shock: counteracts vasodilatory failure and maintains systemic vascular resistance.
  • Cardiogenic shock: enhances cardiac output while supporting blood pressure.
  • Cardiac arrest: provides immediate vasoconstriction to improve coronary and cerebral perfusion during resuscitation.

How It Works

  • Norepinephrine tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, producing potent vasoconstriction and increasing systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, leading to increased myocardial contractility and cardiac output, thereby elevating arterial pressure in acute circulatory failure.

Side Effects

Adverse reactions may occur with intravenous norepinephrine administration.

Common Side Effects

  • Hypertension: excessive rise in blood pressure.
  • Tachycardia: increased heart rate.
  • Headache: pressure sensation.
  • Anxiety or restlessness.
  • Peripheral ischemia at infusion site.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Myocardial ischemia: reduced coronary blood flow.
  • Tissue necrosis: severe extravasation injury.
  • Severe bradycardia: paradoxical slowing of heart rate.
  • Pulmonary edema: fluid accumulation in lungs.

Precautions & Warnings

Use of Noradrenaline Kabi requires careful monitoring and specific safety measures.

  • Blood pressure monitoring: titrate infusion to maintain target MAP.
  • Cardiac rhythm observation: watch for arrhythmias or ischemia.
  • Dose titration: adjust gradually to avoid abrupt hypertension.
  • Extravasation prevention: ensure secure intravenous access and monitor site.
  • Caution in myocardial ischemia: use only when benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine may interact with other agents that affect vascular tone or cardiac function.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension.
  • Indirect sympathomimetics (e.g., ephedrine): additive pressor effect.
  • Beta‑blockers: may blunt desired cardiac response.

Moderate Interactions (Monitor Closely)

  • Tricyclic antidepressants: potential for increased blood pressure.
  • Calcium channel blockers: may enhance hypotensive episodes if norepinephrine is weaned.
  • Diuretics: volume depletion can amplify pressor response.

Frequently Asked Questions

Noradrenaline Kabi is used in acute care to manage severe hypotension, septic shock, cardiogenic shock, and cardiac arrest. It acts as a vasopressor to raise blood pressure and improve organ perfusion when other measures are insufficient.

Norepinephrine tartrate directly stimulates alpha‑1 adrenergic receptors causing vasoconstriction, and beta‑1 receptors in the heart to increase contractility. This dual action raises systemic vascular resistance and cardiac output, helping restore adequate blood pressure in critical situations.

The dose of Noradrenaline Kabi is individualized by the prescribing clinician based on the patient’s hemodynamic status. Infusion rates are titrated to achieve target blood pressure and are adjusted continuously during therapy.

The safety of Noradrenaline Kabi in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Noradrenaline Kabi is a first‑line vasopressor because of its strong alpha‑1 activity and modest beta‑1 effect, offering reliable blood pressure support with less tachycardia than pure alpha agonists. Alternatives such as dopamine or phenylephrine have different receptor profiles and may be chosen based on specific clinical scenarios.

Noradrenaline Kabi should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

The product is supplied as a sterile solution for intravenous infusion. It is typically administered through a central venous catheter, with the infusion rate adjusted continuously based on blood pressure and clinical response.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, and tissue necrosis from extravasation. Continuous hemodynamic monitoring and careful infusion site management are essential to mitigate these hazards.

Patients with known hypersensitivity to norepinephrine or any excipients, those with uncontrolled hypertension, or individuals in whom vasoconstriction could worsen tissue perfusion (e.g., severe peripheral vascular disease) should not receive the drug unless clinically justified.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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