Product image of Noradrenaline (Norepinephrine) Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline (Norepinephrine) Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline (Norepinephrine) Aguettant (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenaline (Norepinephrine) Aguettant, is an adrenergic agonist presented as an injectable solution for intravenous use. It is employed to raise blood pressure in patients with acute hypotension, various forms of shock, and during cardiac arrest in critical care settings.

GNH India supplies Noradrenaline (Norepinephrine) Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with established cold‑chain logistics and regulatory expertise to meet diverse market requirements.

Manufacturer / TM Owner

Laboratoire Aguettant

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Noradrenaline (norepinephrine) is an adrenergic vasopressor used to manage conditions characterized by low blood pressure.

  • Acute hypotension: restores systemic vascular resistance and improves perfusion pressure.
  • Cardiogenic shock: supports hemodynamics by increasing cardiac output and arterial pressure.
  • Cardiac arrest: provides immediate vasoconstriction to facilitate coronary and cerebral perfusion during resuscitation.

How It Works

  • Noradrenaline acts as a direct agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and at beta‑1 receptors in the heart, enhancing contractility and heart rate. The combined alpha‑1 mediated increase in systemic vascular resistance and beta‑1 mediated rise in cardiac output elevates arterial pressure, making it effective for rapid hemodynamic support. These effects are dose‑dependent and occur within minutes after intravenous administration, allowing clinicians to titrate the infusion to target mean arterial pressure.

Side Effects

Noradrenaline may be associated with a range of adverse reactions, varying from frequent to rare but serious.

Common Side Effects

  • Headache: transient headache due to vascular changes.
  • Tachycardia: increased heart rate.
  • Arrhythmia: ectopic beats or rhythm disturbances.
  • Extravasation: local pain and tissue irritation at the infusion site.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in blood pressure.
  • Myocardial ischemia: reduced coronary perfusion leading to chest pain.
  • Peripheral ischemia: tissue necrosis from prolonged vasoconstriction.
  • Cardiac arrest: paradoxical event in susceptible patients.

Precautions & Warnings

When using Noradrenaline, careful monitoring and specific safety measures are required.

  • Dose titration: adjust infusion rate to achieve target mean arterial pressure.
  • Cardiovascular monitoring: continuously monitor blood pressure and heart rhythm.
  • Extravasation risk: avoid infiltration; stop infusion immediately if signs appear.
  • Use in pregnancy: only if benefit outweighs risk; limited data available.
  • Drug compatibility: verify compatibility with IV solutions and other medications.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive sympathomimetic effects.
  • Beta‑blockers: may blunt desired cardiac response.
  • Vasopressin: excessive vasoconstriction.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive episodes after discontinuation.
  • Calcium channel blockers: may affect vascular tone.
  • Opioids: may mask signs of hypertension.

Frequently Asked Questions

Noradrenaline (Norepinephrine) Aguettant is a vasopressor indicated for the rapid correction of acute hypotension, various forms of shock, and cardiac arrest. It helps raise systemic blood pressure and improve organ perfusion in critical care settings.

Noradrenaline directly stimulates alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and beta‑1 receptors in the heart, increasing contractility and heart rate. The combined effect raises systemic vascular resistance and cardiac output, leading to an increase in arterial pressure.

The dosing regimen for Noradrenaline is individualized. The prescribing clinician determines the initial infusion rate and subsequent titration based on the patient’s hemodynamic response and the target mean arterial pressure.

Safety data for Noradrenaline in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any potential risk to the fetus or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Both are vasopressors, but phenylephrine is a pure alpha‑1 agonist causing vasoconstriction without significant beta‑1 activity. Noradrenaline also stimulates beta‑1 receptors, providing combined increases in vascular tone and cardiac output, which makes it preferred in many shock states.

Noradrenaline must be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Use aseptic technique during preparation, keep the product in its original packaging until use, and follow cold‑chain procedures during transport.

Noradrenaline is supplied as a sterile injectable solution for intravenous infusion. It is typically administered via a calibrated infusion pump, with the rate adjusted to achieve the desired blood pressure target while the patient is continuously monitored.

Serious adverse events include severe hypertension, myocardial ischemia, peripheral tissue ischemia, and life‑threatening arrhythmias. If any of these occur, the infusion should be stopped or adjusted immediately and the patient receives urgent medical attention.

Contraindications include patients with known hypersensitivity to noradrenaline or its excipients and those with uncorrected severe tachyarrhythmias where further increase in heart rate could be hazardous. Caution is also advised in patients with significant peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Noradrenaline Tartrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT