Product image of Noradrenaline (Norepinephrine) Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline (Norepinephrine) Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline (Norepinephrine) Kabi (Noradrenaline Tartrate)

Norepinephrine, the active ingredient in Noradrenaline (Norepinephrine) Kabi, is a sympathomimetic presented as a sterile injection for intravenous use. It is employed in acute care to raise blood pressure in patients with hypotension, manage septic shock, and support circulation during cardiac arrest.

GNH India supplies Noradrenaline (Norepinephrine) Kabi as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, intensive‑care units, and emergency departments worldwide. The company ensures regulatory compliance, cold‑chain logistics where required, and responsive customer service for global procurement.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Noradrenaline (Norepinephrine) Kabi is a vasopressor used in critical care to counteract low blood pressure.

  • Hypotension: restores adequate arterial pressure in patients with acute hypotension.
  • Septic shock: improves systemic vascular resistance and organ perfusion in septic shock.
  • Cardiac arrest: provides essential vasoconstrictive support during resuscitation efforts.

How It Works

  • Norepinephrine acts as an agonist at alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors on vascular smooth muscle causes vasoconstriction, raising systemic vascular resistance and blood pressure. Activation of beta‑1 receptors in the heart increases contractility and heart rate, enhancing cardiac output and supporting tissue perfusion during shock states.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often related to rapid blood pressure changes.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Peripheral ischemia: reduced blood flow to extremities causing coldness or discoloration.
  • Nausea: gastrointestinal discomfort reported in some patients.

Serious or Rare Side Effects

  • Myocardial ischemia: chest pain or infarction from excessive cardiac workload.
  • Severe hypertension: dangerously high blood pressure requiring immediate intervention.
  • Tissue necrosis at infusion site: extravasation can lead to local tissue damage.
  • Pulmonary edema: fluid accumulation in lungs due to rapid fluid shifts.
  • Cardiac arrest: paradoxical event in susceptible individuals.

Precautions & Warnings

Noradrenaline (Norepinephrine) Kabi requires careful monitoring and specific handling to ensure safety.

  • Continuous blood pressure monitoring: adjust infusion rate to maintain target pressures.
  • Cardiac rhythm observation: watch for arrhythmias, especially tachyarrhythmias.
  • Central venous access: preferred for prolonged infusions to reduce extravasation risk.
  • Caution in uncontrolled hypertension: avoid rapid dose escalation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline (Norepinephrine) Kabi may interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: can precipitate hypertensive crisis.
  • Tricyclic antidepressants: additive vasoconstrictive effects may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt expected tachycardia response.
  • Calcium channel blockers: can enhance hypotensive effects.
  • Vasodilators (e.g., nitroglycerin): may reduce the drug's efficacy, requiring dose adjustments.

Frequently Asked Questions

Noradrenaline (Norepinephrine) Kabi is a prescription‑only vasopressor used in hospital settings to raise blood pressure in patients with acute hypotension, manage septic shock, and provide circulatory support during cardiac arrest.

Norepinephrine activates alpha‑1 receptors causing blood‑vessel constriction and beta‑1 receptors increasing heart contractility. The combined effect elevates systemic vascular resistance and cardiac output, helping restore adequate tissue perfusion during shock.

The dosing regimen is individualized by the treating physician based on the patient’s condition, response, and hemodynamic targets. The prescriber determines the infusion rate and any adjustments needed during therapy.

Safety data for use in pregnancy or lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by the prescribing clinician.

Enquiries are submitted via the product page at gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and import documentation.

Norepinephrine is generally preferred for septic shock because of its strong alpha‑1 mediated vasoconstriction with modest beta‑1 activity, offering balanced blood‑pressure support. Other agents such as dopamine or phenylephrine may have different receptor profiles, influencing heart rate and cardiac output differently.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. It should be kept in its original container until use to maintain stability.

It is supplied as a sterile solution for intravenous injection. The drug is typically administered as a continuous infusion through a calibrated pump, allowing precise control of the infusion rate according to the patient’s hemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, tissue necrosis from extravasation, and life‑threatening arrhythmias. Continuous monitoring of blood pressure, cardiac rhythm, and infusion site is essential to detect and manage these complications promptly.

Patients with uncontrolled hypertension, known hypersensitivity to norepinephrine or any formulation component, and those in whom vasoconstriction could worsen peripheral ischemia should not receive the drug. Contraindications are determined by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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