Product image of Noradrenaline (Norepinephrine) Laboratoire Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline (Norepinephrine) Laboratoire Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline (Norepinephrine) Laboratoire Aguettant (Noradrenaline Tartrate)

Norepinephrine, the active ingredient in Noradrenaline (Norepinephrine) Laboratoire Aguettant, is a sympathomimetic agent presented as an intravenous solution for intravenous administration. It is used to raise blood pressure and improve cardiac output in patients with acute hypotension, cardiogenic shock or septic shock.

GNH India supplies Noradrenaline (Norepinephrine) Laboratoire Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and intensive‑care units worldwide, with distribution across the EU and other regulated markets. All batches meet European Pharmacopoeia standards and are shipped under controlled temperature conditions.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenaline (norepinephrine) is a sympathomimetic cardiovascular agent used to manage severe hypotensive states.

  • Hypotension: restores vascular tone and raises arterial pressure in acute hypotensive episodes, aiding organ perfusion.
  • Cardiogenic shock: enhances myocardial contractility and systemic vascular resistance, improving cardiac output and tissue oxygen delivery in pump failure.
  • Septic shock: counteracts profound vasodilation by stimulating alpha‑1 receptors, supporting blood pressure and organ perfusion during systemic infection.

How It Works

  • Norepinephrine acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors on vascular smooth muscle produces potent vasoconstriction, increasing systemic vascular resistance and arterial pressure. Concurrent beta‑1 activation in the heart enhances myocardial contractility and heart rate, raising cardiac output. The combined effects rapidly elevate blood pressure and improve perfusion in shock states.

Side Effects

Norepinephrine may be associated with a range of adverse reactions, varying from frequent to rare.

Common Side Effects

  • Headache: mild to moderate headache reported during infusion.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Arrhythmia: occasional premature beats or rhythm disturbances.
  • Peripheral ischemia: reduced blood flow to extremities causing coldness or pain.
  • Nausea: occasional nausea or vomiting.

Serious or Rare Side Effects

  • Severe hypertension: abrupt, excessive rise in blood pressure.
  • Myocardial ischemia: chest pain or infarction from increased cardiac workload.
  • Tissue necrosis: extravasation at infusion site leading to local tissue damage.
  • Pulmonary edema: fluid accumulation in lungs due to fluid shifts.
  • Anaphylaxis: rare hypersensitivity reaction with rash, bronchospasm, hypotension.

Precautions & Warnings

When using norepinephrine, clinicians should observe specific safety measures to minimize risks.

  • Dose titration: adjust infusion rate based on continuous blood pressure monitoring.
  • Cardiac monitoring: observe for arrhythmias and signs of myocardial ischemia.
  • Extravasation risk: avoid peripheral administration; use central venous line when possible.
  • Fluid status: ensure adequate intravascular volume before initiating therapy.
  • Concomitant vasopressors: evaluate cumulative pressor effect when combined with other agents.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine can interact with several drugs, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: may potentiate hypertensive response.
  • Tricyclic antidepressants: increase risk of severe hypertension.
  • Beta‑blockers: can blunt desired tachycardia and reduce cardiac output.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasodilatory effects, requiring dose adjustment.
  • Diuretics: can exacerbate intravascular volume depletion, affecting response.
  • Sedatives or anesthetics: may mask signs of excessive pressor effect.

Frequently Asked Questions

Noradrenaline (norepinephrine) is employed in acute care to treat severe hypotension, cardiogenic shock and septic shock. By raising systemic vascular resistance and supporting cardiac output, it helps restore adequate blood pressure and organ perfusion in critically ill patients.

Norepinephrine directly stimulates alpha‑1 receptors causing vasoconstriction and beta‑1 receptors increasing heart contractility and rate. The combined actions raise arterial pressure and improve cardiac output, making it effective for rapid hemodynamic stabilization in shock states.

The dose of norepinephrine is individualized by the prescribing clinician. It is titrated to the patient’s blood pressure response, usually starting at a low infusion rate and adjusting based on continuous hemodynamic monitoring to achieve target pressures.

Safety data for norepinephrine in pregnancy and lactation are limited. Because potential risks cannot be excluded, it should be used only if the clinical benefit justifies the potential hazard to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Norepinephrine is generally preferred over dopamine because it provides stronger alpha‑1 mediated vasoconstriction with less tachyarrhythmia risk. Compared with epinephrine, it has a more balanced alpha‑1/beta‑1 profile, offering effective blood pressure support while limiting excessive heart rate acceleration.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. It should be kept in its original packaging until use to maintain stability and potency.

Norepinephrine is supplied as an intravenous solution and is administered by continuous infusion, preferably through a central venous catheter. The infusion rate is adjusted according to real‑time blood pressure measurements to achieve the desired hemodynamic effect.

Clinicians should monitor for severe hypertension, myocardial ischemia or infarction, and tissue necrosis at the infusion site due to extravasation. Prompt recognition and management of these events are essential to prevent life‑threatening complications.

Norepinephrine is contraindicated in patients with known hypersensitivity to the drug or its excipients, and should be used with caution in individuals with uncontrolled hypertension, severe peripheral vascular disease, or those at high risk for cardiac ischemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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