Product image of Noradrenaline Sans Sulfites Viatris (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline Sans Sulfites Viatris

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline Sans Sulfites Viatris (Noradrenaline Tartrate)

Noradrenaline, the active ingredient in Noradrenaline Sans Sulfites Viatris, is an adrenergic agonist presented as an injection solution for intravenous use. It treats acute hypotension, septic shock, cardiac arrest and post‑cardiac surgery low output syndrome in hospital settings under close medical supervision and intensive care units.

GNH India supplies Noradrenaline Sans Sulfites Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide with rigorous quality assurance and reliable logistics for critical care medicines.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Noradrenaline is a vasopressor that acts on the adrenergic system to restore blood pressure in critical care settings.

  • Acute hypotension: raises systemic vascular resistance to increase arterial pressure.
  • Septic shock: improves organ perfusion by vasoconstriction and enhanced cardiac output.
  • Cardiac arrest: provides circulatory support during resuscitation efforts.
  • Post‑cardiac surgery low output syndrome: augments cardiac output and systemic pressure.

How It Works

  • Noradrenaline acts as a direct agonist at α1‑adrenergic receptors causing peripheral vasoconstriction and at β1‑adrenergic receptors increasing myocardial contractility and heart rate. Through activation of intracellular signaling pathways that increase calcium influx in vascular smooth muscle and cardiac myocytes, the drug further enhances contractile force. The combined effect raises systemic vascular resistance and cardiac output, leading to rapid elevation of arterial pressure in patients with circulatory failure.

Side Effects

Noradrenaline may be associated with a range of adverse reactions, varying from frequent to rare but serious.

Common Side Effects

  • Tachycardia: increased heart rate.
  • Headache: transient cranial pain.
  • Nausea: mild gastrointestinal upset.
  • Peripheral ischemia: reduced blood flow to extremities causing discomfort.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening rhythm disturbances.
  • Myocardial ischemia: reduced oxygen supply to heart muscle.
  • Severe hypertension: abrupt excessive rise in blood pressure.
  • Tissue necrosis at infusion site: local tissue death due to extravasation.

Precautions & Warnings

When using Noradrenaline, careful clinical monitoring and adherence to handling guidelines are essential.

  • Cardiovascular monitoring: continuous blood pressure and heart rate assessment.
  • Dose titration: adjust infusion rate to achieve target MAP while avoiding excessive hypertension.
  • Contraindications: avoid in patients with known hypersensitivity to noradrenaline or sulfite‑containing products.
  • Drug interactions: monitor closely when combined with beta‑blockers or MAO inhibitors.
  • Extravasation risk: stop infusion immediately if signs of infiltration appear and manage according to protocol.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline can interact with several medicines, influencing its pressor effect or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: may cause hypertensive crisis.
  • Tricyclic antidepressants: potentiate vasoconstriction and raise blood pressure.
  • Ergot alkaloids: increase risk of severe vasospasm.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt tachycardia response.
  • Calcium channel blockers: additive effects on blood pressure.
  • Diuretics: may alter intravascular volume and affect response.
  • Vasodilators: may reduce efficacy of noradrenaline.

Frequently Asked Questions

Noradrenaline Sans Sulfites Viatris is used in hospital and intensive‑care settings to treat acute hypotension, septic shock, cardiac arrest, and post‑cardiac surgery low output syndrome by rapidly raising blood pressure and supporting cardiac output.

Noradrenaline acts as a direct agonist at α1‑adrenergic receptors, causing peripheral vasoconstriction, and at β1‑adrenergic receptors, increasing heart contractility and rate. The combined actions raise systemic vascular resistance and cardiac output, restoring arterial pressure in circulatory failure.

The dose of Noradrenaline Sans Sulfites Viatris is determined individually by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. No fixed regimen is provided here.

Safety data for Noradrenaline in pregnancy or lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Noradrenaline is the first‑line vasopressor for most forms of acute hypotension because of its strong α1‑mediated vasoconstriction and modest β1 activity. Compared with agents such as dopamine or phenylephrine, it offers more predictable blood pressure control with fewer tachyarrhythmic effects.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. It should be kept in its original packaging to maintain sterility and potency until use.

Noradrenaline is supplied as a sterile injection solution for intravenous infusion. It is typically administered via a calibrated infusion pump, with the rate adjusted continuously to achieve the desired mean arterial pressure while monitoring cardiovascular parameters.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and tissue necrosis if the drug extravasates from the vein. Continuous hemodynamic monitoring and prompt management of infusion site complications are essential to mitigate these risks.

Patients with known hypersensitivity to noradrenaline or sulfite‑containing products, or those in whom vasoconstriction is contraindicated (e.g., severe peripheral vascular disease), should not receive this medication. Clinical judgment is required for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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