Product image of Noradrenalină Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenalină Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalină Kabi (Noradrenaline Tartrate)

Norepinephrine, the active ingredient in Noradrenalină Kabi, is a sympathomimetic (alpha‑adrenergic agonist) presented as an injectable solution for intravenous use. It treats acute hypotension and various shock states in hospitalized patients who require rapid circulatory support.

GNH India supplies Noradrenalină Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Romania Srl

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Indications & Clinical Uses

  • Noradrenaline acts on the sympathetic cardiovascular pathway to restore blood pressure in critical care settings.
  • Acute hypotension: raises systemic blood pressure to maintain organ perfusion.
  • Septic shock: supports vascular tone and cardiac output in sepsis‑related hypotension.
  • Cardiogenic shock: improves myocardial contractility and systemic perfusion in heart‑failure‑related shock.
  • Post‑operative hypotension: corrects low blood pressure after surgery.

How It Works

  • Norepinephrine binds directly to α1‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction, and to β1‑adrenergic receptors on cardiac myocytes, increasing heart‑rate and contractility. The combined α1‑mediated increase in systemic vascular resistance and β1‑mediated cardiac output elevates arterial pressure, restoring perfusion in shock states.

Side Effects

Adverse reactions may vary with dose, infusion rate, and patient condition.

Common Side Effects

  • Tachycardia: rapid heart rate due to β1 stimulation.
  • Hypertension: excessive rise in blood pressure from α1 vasoconstriction.
  • Arrhythmia: irregular cardiac rhythm, especially in susceptible patients.
  • Headache: vascular changes can trigger cranial discomfort.
  • Anxiety or restlessness: central sympathetic activation.
  • Nausea: gastrointestinal upset during infusion.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary blood flow from severe vasoconstriction.
  • Severe hypertension: dangerous elevation of arterial pressure.
  • Tissue necrosis at infusion site: extravasation injury.
  • Pulmonary edema: fluid accumulation due to increased afterload.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Cardiac arrest: profound circulatory collapse in extreme cases.

Precautions & Warnings

  • Careful monitoring and risk assessment are essential when using norepinephrine.
  • Blood pressure monitoring: continuous invasive measurement to titrate infusion.
  • Cardiac monitoring: ECG surveillance for arrhythmias.
  • Dose titration: adjust gradually to avoid abrupt hemodynamic shifts.
  • Coronary artery disease: use with caution, as increased workload may precipitate ischemia.
  • Uncontrolled hypertension: contraindicated; avoid rapid escalation.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine may have additive or antagonistic effects with several drug classes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension.
  • Tricyclic antidepressants: potentiation of vasoconstrictive response.
  • Other potent vasopressors: can cause excessive vascular tone.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt β1‑mediated cardiac effects.
  • ACE inhibitors or ARBs: may enhance hypotensive episodes if norepinephrine is withdrawn.
  • Calcium channel blockers: possible additive effects on vascular resistance.

Frequently Asked Questions

Noradrenalină Kabi contains norepinephrine, a vasopressor used in hospitals to treat acute hypotension, septic shock, cardiogenic shock, cardiac arrest support, and post‑operative low blood pressure. It helps raise systemic vascular resistance and cardiac output to maintain vital organ perfusion.

Norepinephrine acts as a direct agonist at α1‑adrenergic receptors, causing blood‑vessel constriction, and at β1‑adrenergic receptors, increasing heart‑rate and contractility. The combined effect raises arterial pressure and improves cardiac output, which is essential in shock and severe hypotension.

The dose of norepinephrine is individualized. A qualified prescriber determines the infusion rate based on the patient’s blood‑pressure response, underlying condition, and continuous monitoring. No fixed regimen is provided in the product description.

Safety data for norepinephrine in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under strict medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Norepinephrine is often preferred for septic shock because it provides strong α1‑mediated vasoconstriction with modest β1 activity, balancing blood‑pressure support and cardiac workload. Compared with dopamine, it has a lower risk of tachyarrhythmias, and unlike phenylephrine, it also supports heart‑rate and contractility.

The injectable solution must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial. Before use, allow the product to reach room temperature if required, and inspect for particulate matter or discoloration.

Noradrenalină Kabi is given intravenously, typically as a continuous infusion. The infusion is started at a low rate and titrated according to the patient’s blood‑pressure response, with frequent hemodynamic monitoring to avoid overshoot or under‑correction.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, tissue necrosis from extravasation, and pulmonary edema. Immediate recognition and management of these events are critical, and infusion rates should be adjusted promptly under continuous monitoring.

Patients with known hypersensitivity to norepinephrine or any formulation component should avoid the product. It is also contraindicated in uncontrolled hypertension, pheochromocytoma, or when other vasopressors have already caused excessive vasoconstriction without benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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