Noradrenalin Léčiva (Noradrenaline Tartrate)

Noradrenaline tartrate acts on the sympathetic vascular pathway to restore arterial tone in severe hypotensive conditions.

• Hypotension: rapidly increases systemic vascular resistance to raise arterial pressure.
• Septic shock: counteracts vasodilatory failure and maintains target mean arterial pressure.
• Cardiac arrest: supports coronary and cerebral perfusion during resuscitation.
• Post‑operative hypotension: stabilises haemodynamics after major surgery.

• Noradrenaline tartrate is a direct agonist at alpha‑1 adrenergic receptors, producing potent vasoconstriction and increasing systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, enhancing contractility and cardiac output, thereby elevating mean arterial pressure in acute circulatory failure.

Noradrenaline tartrate may cause a range of adverse reactions that require monitoring.

Common Side Effects

• Tachycardia: increased heart rate due to beta‑1 stimulation.
• Hypertension: excessive rise in blood pressure if dose overshoots target.
• Headache: related to rapid changes in vascular tone.
• Nausea: gastrointestinal discomfort during infusion.

Serious or Rare Side Effects

• Myocardial ischemia: reduced coronary perfusion from intense vasoconstriction.
• Severe peripheral ischemia: risk of tissue necrosis at infusion sites.
• Pulmonary edema: fluid accumulation secondary to increased afterload.
• Anaphylaxis: rare hypersensitivity reaction requiring immediate intervention.

Noradrenaline tartrate should be used with careful clinical oversight.

• Cardiovascular monitoring: continuous blood pressure and ECG monitoring required.
• Dose titration: adjust infusion rate to achieve target mean arterial pressure.
• Renal/hepatic impairment: use with caution and monitor organ function.
• Concomitant MAO inhibitors: avoid due to risk of hypertensive crisis.
• Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
• Store at ambient temperature: keep in original container, protect from light and moisture.

Noradrenaline tartrate can interact with several drug classes.

Major Interactions (Avoid)

• MAO inhibitors: may precipitate severe hypertension.
• Tricyclic antidepressants: additive pressor effects increase risk of hypertensive episodes.
• Beta‑blockers: can blunt the desired cardiac response to noradrenaline.

Moderate Interactions (Monitor Closely)

• Vasodilators (e.g., nitroglycerin): may require higher noradrenaline doses to maintain pressure.
• Calcium channel blockers: possible additive cardiovascular effects.
• Diuretics: may exacerbate hypotension if noradrenaline dosing is insufficient.