Product image of Noradrenaline (Tartrate) (Sans Sulfites) Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline (Tartrate) (Sans Sulfites) Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline (Tartrate) (Sans Sulfites) Aguettant (Noradrenaline Tartrate)

Norepinephrine tartrate, the active ingredient in Noradrenaline (Tartrate) (Sans Sulfites) Aguettant, is a sympathomimetic presented as a solution for injection for intravenous use. It treats hypotension, septic shock and cardiac arrest in acute care settings.

GNH India supplies Noradrenaline (Tartrate) (Sans Sulfites) Aguettant as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenaline (Tartrate) is a vasopressor that acts on the sympathetic nervous system to raise blood pressure.

  • Hypotension: restores arterial pressure in patients with acute low blood pressure.
  • Septic shock: supports circulatory function by increasing systemic vascular resistance.
  • Cardiac arrest: provides temporary hemodynamic support during resuscitation efforts.

How It Works

  • Norepinephrine tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, producing potent vasoconstriction and raising systemic vascular resistance. It also stimulates beta‑1 receptors, modestly increasing cardiac contractility and heart rate, which together elevate mean arterial pressure and improve organ perfusion in shock states.

Side Effects

Noradrenaline (Tartrate) may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Tachycardia: increased heart rate.
  • Hypertension: elevated blood pressure.
  • Headache: mild to moderate intensity.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Cardiac arrhythmia: potentially life‑threatening rhythm disturbances.
  • Tissue necrosis: extravasation leading to local tissue damage.
  • Severe hypertension crisis: dangerously high blood pressure.

Precautions & Warnings

When using Noradrenaline (Tartrate), clinicians should observe several safety measures.

  • Dose titration: adjust infusion rate based on continuous blood pressure monitoring.
  • Cardiac monitoring: observe for arrhythmias and ischemia during therapy.
  • Fluid status: ensure adequate intravascular volume before initiating infusion.
  • Concomitant vasopressors: avoid simultaneous use with other potent vasoconstrictors unless clinically justified.
  • Patient population: use with caution in patients with pre‑existing coronary artery disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline (Tartrate) can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: may cause hypertensive crisis.
  • Tricyclic antidepressants: increase risk of severe hypertension.
  • Beta‑blockers: can blunt the expected increase in heart rate.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasoconstrictive effect.
  • Diuretics: can exacerbate hypovolemia, affecting response.
  • Inhaled anesthetics: may potentiate cardiovascular instability.

Frequently Asked Questions

Noradrenaline (Tartrate) (Sans Sulfites) Aguettant is a prescription vasopressor indicated for the acute management of severe hypotension, septic shock, and as a temporary circulatory support during cardiac arrest. It is administered in intensive care or emergency settings to rapidly raise blood pressure and improve organ perfusion.

Norepinephrine tartrate directly stimulates alpha‑1 adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction and an increase in systemic vascular resistance. It also activates beta‑1 receptors in the heart, modestly enhancing contractility and heart rate, together resulting in elevated mean arterial pressure.

The dose of Noradrenaline (Tartrate) is individualized and set by the prescribing clinician. It is typically titrated by continuous intravenous infusion, guided by real‑time blood pressure measurements and the patient’s hemodynamic response, rather than a fixed standard regimen.

Safety data for norepinephrine tartrate in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, and it should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Norepinephrine tartrate has both alpha‑1 and beta‑1 activity, offering vasoconstriction plus modest cardiac stimulation, whereas phenylephrine is a pure alpha‑1 agonist and may reduce heart rate. Clinicians often prefer norepinephrine for septic shock because its combined actions better maintain cardiac output while raising blood pressure.

The solution should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial, and avoid prolonged exposure to temperatures above the recommended range to preserve stability.

Noradrenaline (Tartrate) is supplied as a sterile solution for intravenous infusion. It is typically administered through a calibrated infusion pump, allowing precise titration of the infusion rate based on continuous hemodynamic monitoring.

Serious risks include cardiac arrhythmias, severe hypertension, and tissue necrosis if the drug extravasates from the vein. Continuous cardiovascular monitoring and careful intravenous access management are essential to detect and mitigate these complications promptly.

Patients with known hypersensitivity to norepinephrine or any component of the formulation should not receive the product. Caution is also advised in individuals with severe peripheral vascular disease, uncontrolled hypertension, or those receiving other potent vasoconstrictors without clear clinical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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