Product image of Noradrenaline Viatris (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline Viatris

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline Viatris (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenaline Viatris, is a sympathomimetic (vasopressor) presented as an injectable solution for intravenous use. It is employed to raise blood pressure in acute hypotensive states such as septic shock, cardiac arrest, and post‑operative hypotension.
GNH India supplies Noradrenaline Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

  • Noradrenaline acts on the adrenergic system to provide rapid vasoconstriction and cardiac support in critical care settings.
  • Acute hypotension: restores systemic vascular resistance and improves perfusion pressure.
  • Septic shock: counteracts vasodilatory shock to maintain mean arterial pressure.
  • Cardiac arrest: supports coronary and cerebral perfusion during resuscitation.
  • Post‑operative hypotension: stabilizes blood pressure after surgery.

How It Works

  • Noradrenaline Tartrate is an agonist at α1‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction, and at β1‑adrenergic receptors on cardiac myocytes, increasing contractility and heart rate. The combined α‑ and β‑stimulating actions raise systemic vascular resistance and cardiac output, thereby elevating arterial blood pressure in acute circulatory failure.

Side Effects

Noradrenaline may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: transient headache due to rapid blood pressure changes.
  • Tachycardia: increased heart rate from β1 stimulation.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Nausea: gastrointestinal discomfort.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Severe hypertension: excessive rise in blood pressure.
  • Tissue necrosis at injection site: local tissue damage if extravasation occurs.
  • Myocardial ischemia: reduced coronary perfusion causing chest pain.

Precautions & Warnings

  • When using Noradrenaline, careful monitoring and specific safety measures are required.
  • Dose titration: adjust infusion rate to target blood pressure.
  • Cardiovascular monitoring: continuous ECG and arterial pressure monitoring required.
  • Extravasation risk: avoid infiltration; stop infusion immediately if leakage suspected.
  • Concomitant MAO inhibitors: contraindicated due to risk of hypertensive crisis.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: can cause severe hypertension.
  • Tricyclic antidepressants: additive sympathomimetic effect.
  • β‑blockers: may blunt β1 mediated cardiac response.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasoconstriction.
  • Diuretics: may potentiate hypotensive episodes if dose reduced.
  • Inhaled anesthetics: may alter vascular tone.

Frequently Asked Questions

Noradrenaline Viatris is an injectable vasopressor used in emergency and intensive‑care settings to treat acute hypotension, septic shock, cardiac arrest, and post‑operative hypotension by rapidly increasing blood pressure and supporting cardiac output.

Noradrenaline Tartrate stimulates α1‑adrenergic receptors on blood vessels, causing vasoconstriction, and β1‑adrenergic receptors on the heart, enhancing contractility and heart rate. This dual action raises systemic vascular resistance and cardiac output, restoring arterial pressure in critically ill patients.

The dose of Noradrenaline Viatris is individualized; a prescriber determines the infusion rate based on the patient’s hemodynamic response, target blood pressure, and clinical condition. Dosing is titrated in real‑time under continuous monitoring.

Safety data for Noradrenaline Tartrate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Noradrenaline is the first‑line vasopressor for most forms of distributive shock because of its potent α1‑mediated vasoconstriction and modest β1 activity. Compared with dopamine, it has less tachyarrhythmic risk, and unlike phenylephrine it also supports cardiac output through β1 stimulation.

Noradrenaline Viatris must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

The product is supplied as an injectable solution for intravenous infusion. It is typically administered via a calibrated infusion pump, allowing precise titration of the infusion rate to achieve the desired hemodynamic effect.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, tissue necrosis from extravasation, and pulmonary edema. Continuous cardiovascular monitoring is essential to detect and manage these complications promptly.

Patients with known hypersensitivity to noradrenaline or its excipients, those receiving monoamine oxidase inhibitors, and individuals with uncontrolled hypertension should not receive Noradrenaline Viatris. Use in pregnancy, lactation, or pediatric populations requires careful risk‑benefit assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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