Product image of Noraminophenazoni Fono Vii. Naturland (Metamizole Sodium Monohydrate) supplied by GNH India

Noraminophenazoni Fono Vii. Naturland

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Noraminophenazoni Fono Vii. Naturland (Metamizole Sodium Monohydrate)

Metamizole sodium monohydrate, the active ingredient in Noraminophenazoni Fono Vii. Naturland, is a pyrazolone presented as a rectal formulation for rectal use. It provides analgesic and antipyretic effects for the treatment of pain, fever and colic in adults.

GNH India supplies Noraminophenazoni Fono Vii. Naturland as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Naturland Magyarország Kft.

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Indications & Clinical Uses

Metamizole sodium monohydrate is used to manage pain and fever through inhibition of prostaglandin-mediated pathways.

  • Pain: reduces moderate to severe acute pain.
  • Fever: lowers elevated body temperature.
  • Colic: alleviates abdominal cramping associated with colic.

How It Works

  • Metamizole sodium monohydrate inhibits cyclooxygenase activity, leading to decreased synthesis of prostaglandins and other inflammatory mediators. This reduction in prostaglandin levels diminishes nociceptive signaling and thermoregulatory responses, producing analgesic and antipyretic effects. The precise molecular interactions are not fully elucidated, but the overall effect is a dampening of inflammatory pathways that contribute to pain and fever.

Side Effects

Metamizole sodium monohydrate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Dizziness
  • Rash
  • Headache

Serious or Rare Side Effects

  • Agranulocytosis
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Anaphylactic reaction

Precautions & Warnings

When using Metamizole sodium monohydrate, consider the following safety measures.

  • Blood count monitoring: check for neutropenia before and during therapy.
  • Renal function assessment: adjust use in patients with renal impairment.
  • Hypersensitivity evaluation: avoid in individuals with known allergy to pyrazolones.
  • History of agranulocytosis: contraindicated in patients with prior episodes.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Metamizole sodium monohydrate can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concurrent myelosuppressive agents: increased risk of severe blood dyscrasias.
  • Other NSAIDs or pyrazolones: additive gastrointestinal and renal toxicity.
  • Anticoagulants: heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: potential for enhanced hypotensive effect.
  • Diuretics: may exacerbate electrolyte disturbances.
  • Alcohol: increased risk of gastrointestinal irritation.

Frequently Asked Questions

Noraminophenazoni Fono Vii. Naturland contains metamizole sodium, which is employed to relieve moderate to severe pain, reduce fever, and treat colic. It is commonly used in adult patients when rapid analgesic and antipyretic effects are required.

Metamizole sodium works by inhibiting cyclooxygenase enzymes, which lowers the production of prostaglandins—key mediators of pain, inflammation, and fever. This reduction in prostaglandin levels diminishes nociceptive signaling and resets the hypothalamic set‑point for body temperature, providing analgesic and antipyretic benefits.

The appropriate dose of Noraminophenazoni Fono Vii. Naturland is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual health factors. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for metamizole sodium in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metamizole sodium belongs to the pyrazolone class, offering strong analgesic and antipyretic effects comparable to certain NSAIDs but with a distinct safety profile, notably a risk of agranulocytosis. Unlike opioids, it does not cause respiratory depression, making it a useful alternative for non‑opioid pain management when appropriate.

Store Noraminophenazoni Fono Vii. Naturland at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and extreme heat to maintain stability and potency.

The product is formulated for rectal administration. It should be inserted according to the prescribing information, typically using a suitable applicator, and the patient should remain in a comfortable position to ensure proper absorption.

The most serious adverse reactions include agranulocytosis, severe skin disorders such as Stevens‑Johnson syndrome, and anaphylactic shock. Patients should be monitored for signs of infection, skin changes, or allergic reactions, and immediate medical attention is required if these occur.

Metamizole sodium should be avoided in individuals with a known hypersensitivity to pyrazolones, a history of agranulocytosis, severe hepatic or renal impairment, and in patients currently receiving other myelosuppressive therapies unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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