Product image of Nordimet (Methotrexate) supplied by GNH India

Nordimet

Active Ingredient:
Methotrexate
Origin:
EU

Nordimet (Methotrexate)

Methotrexate, the active ingredient in Nordimet, is an antimetabolite presented as an injection for subcutaneous use. It is employed to modify disease processes in rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, and certain malignancies such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma.

GNH India supplies Nordimet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics for this essential therapy.

Manufacturer / TM Owner

Nordic Group B.V.

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Indications & Clinical Uses

Methotrexate is used as a disease‑modifying antirheumatic drug (DMARD) and antimetabolite in several immune‑mediated and oncologic conditions.

  • Rheumatoid arthritis: reduces joint inflammation and slows structural damage.
  • Psoriasis: improves skin lesions and reduces plaque formation.
  • Juvenile idiopathic arthritis: controls disease activity and prevents joint damage.
  • Acute lymphoblastic leukemia: interferes with malignant cell proliferation.
  • Non‑Hodgkin lymphoma: contributes to cytoreduction as part of combination therapy.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, decreasing tetrahydrofolate production and thereby limiting purine and pyrimidine synthesis. This reduction in DNA, RNA and protein synthesis hampers rapidly dividing cells, including immune‑mediated inflammatory cells and malignant lymphocytes. The drug also promotes accumulation of adenosine, which exerts anti‑inflammatory effects, contributing to its efficacy in rheumatic diseases.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Fatigue: general tiredness or weakness.
  • Oral ulcers: painful sores in the mouth.
  • Elevated liver enzymes: mild hepatic enzyme rise.
  • Low blood counts: mild leukopenia or anemia.

Serious or Rare Side Effects

  • Severe liver toxicity: potential hepatitis or fibrosis.
  • Pulmonary toxicity: interstitial pneumonitis or fibrosis.
  • Bone marrow suppression: profound pancytopenia.
  • Renal impairment: acute kidney injury.
  • Severe infection: opportunistic infections due to immunosuppression.

Precautions & Warnings

When prescribing methotrexate, clinicians should observe several safety precautions to minimize risk.

  • Pregnancy contraindication: avoid use in pregnancy (Category X) and ensure effective contraception.
  • Liver monitoring: perform baseline and periodic liver function tests.
  • Renal function: assess creatinine clearance before initiation and during therapy.
  • Hematologic surveillance: monitor complete blood count regularly.
  • Drug interactions: review concomitant medications that may increase toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or increase toxicity.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase methotrexate toxicity.
  • Proton pump inhibitors (omeprazole, esomeprazole): can raise serum methotrexate levels.
  • Trimethoprim‑sulfamethoxazole: enhances myelosuppression risk.

Moderate Interactions (Monitor Closely)

  • Azathioprine or mycophenolate: additive immunosuppression.
  • Live vaccines: risk of infection due to immunosuppression.
  • Phenytoin or carbamazepine: may reduce methotrexate efficacy.

Frequently Asked Questions

Nordimet, containing methotrexate, is indicated for rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, and certain cancers such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma. In each case it works to modify disease activity, reduce inflammation, and limit abnormal cell growth.

Methotrexate blocks the enzyme dihydrofolate reductase, which reduces the production of tetrahydrofolate needed for DNA, RNA and protein synthesis. This limits the proliferation of rapidly dividing cells, including inflammatory immune cells and malignant lymphocytes, and also increases adenosine levels that provide anti‑inflammatory effects.

The dose of Nordimet is individualized by the prescribing clinician based on the specific condition, patient weight, renal and hepatic function, and response to therapy. Dosage adjustments may be required over time, and the prescriber will set the exact regimen.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal harm. It is also not recommended during breastfeeding, as it can be excreted in milk and affect the infant.

To request Nordimet, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Compared with other DMARDs such as leflunomide or biologic agents, methotrexate offers a well‑established efficacy profile and is often used as first‑line therapy. It is generally less expensive than biologics but may require more laboratory monitoring. Choice of therapy depends on disease severity, patient tolerance and physician assessment.

Nordimet should be stored at 2‑8 °C (refrigerated), protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and potency.

Nordimet is given as a subcutaneous injection. The healthcare professional selects an appropriate injection site, cleans the area with an antiseptic, and administers the dose using a sterile needle and syringe according to standard aseptic technique.

The most serious adverse risks include severe liver toxicity, bone‑marrow suppression leading to pancytopenia, pulmonary toxicity such as interstitial pneumonitis, and heightened susceptibility to serious infections. Patients should be monitored regularly for signs of these conditions.

Nordimet should be avoided in pregnant or breastfeeding individuals, patients with known hypersensitivity to methotrexate, those with severe hepatic or renal impairment, and patients with active, uncontrolled infections. Clinicians must also assess for contraindications before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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