Product image of Norepinephrine Basi (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Basi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Basi (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Norepinephrine Basi, is a sympathomimetic presented as an injectable solution for intravenous use. It is classified as a vasopressor and is employed to rapidly raise blood pressure in acute hypotensive states and various forms of shock in critically ill patients.

GNH India supplies Norepinephrine Basi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Norepinephrine Basi acts on the sympathetic nervous system to support circulatory function in severe shock states.

  • Hypotension: restores arterial pressure when conventional fluids are insufficient.
  • Septic shock: improves systemic perfusion and organ oxygen delivery.
  • Cardiogenic shock: enhances cardiac output while maintaining vascular tone.
  • Cardiac arrest (adjunct): augments coronary and cerebral perfusion during resuscitation efforts.

How It Works

  • Noradrenaline tartrate is a direct agonist of alpha‑1 adrenergic receptors, causing potent vasoconstriction, and of beta‑1 receptors, increasing myocardial contractility and heart rate. The combined alpha‑1 and beta‑1 stimulation produces a rapid rise in systemic vascular resistance and cardiac output, leading to an immediate increase in arterial blood pressure.

Side Effects

Norepinephrine Basi may be associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often related to rapid blood pressure changes.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Arrhythmia: irregular heart rhythms, especially in predisposed patients.
  • Peripheral ischemia: reduced blood flow to extremities causing pain or discoloration.
  • Nausea: gastrointestinal discomfort during infusion.
  • Anxiety: heightened nervousness or restlessness.

Serious or Rare Side Effects

  • Myocardial ischemia: chest pain or infarction from excessive coronary vasoconstriction.
  • Severe hypertension: dangerously high blood pressure requiring immediate intervention.
  • Tissue necrosis at infusion site: local injury if extravasation occurs.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Pulmonary edema: fluid accumulation in lungs due to rapid fluid shifts.
  • Anaphylaxis: rare severe allergic reaction requiring emergency treatment.

Precautions & Warnings

When using Norepinephrine Basi, clinicians should observe specific safety measures.

  • Monitor blood pressure: adjust infusion rate to maintain target pressures.
  • Cardiac monitoring: continuous ECG to detect tachyarrhythmias.
  • Use caution in coronary artery disease: risk of myocardial ischemia.
  • Avoid rapid bolus in peripheral vascular disease: may worsen limb ischemia.
  • Adjust dose in renal/hepatic impairment: limited data, titrate carefully.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine Basi can interact with several drug classes, influencing its efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive sympathomimetic effects.
  • Beta‑blockers: may blunt desired hemodynamic response.
  • Ergot alkaloids: potential for severe vasoconstriction.
  • Monoamine oxidase inhibitors: same as MAO inhibitors, heightened risk.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may reduce drug effectiveness.
  • Calcium channel blockers: can affect vascular tone.
  • Diuretics: may exacerbate hypotension.
  • Sedatives: may mask signs of over‑infusion.
  • ACE inhibitors: may potentiate hypotensive episodes.

Frequently Asked Questions

Norepinephrine Basi is indicated for the rapid management of severe hypotension, septic shock, cardiogenic shock, and as an adjunct in cardiac arrest. It is used in intensive care settings to restore adequate blood pressure and organ perfusion when conventional fluid therapy is insufficient.

Noradrenaline tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, causing vasoconstriction, and at beta‑1 receptors, increasing heart contractility and rate. The combined effect raises systemic vascular resistance and cardiac output, resulting in an immediate increase in arterial pressure.

The dosing regimen for Norepinephrine Basi is determined by the prescribing clinician based on the patient’s hemodynamic status, weight, and response to therapy. It is administered intravenously as a continuous infusion, with the rate titrated to achieve target blood pressure goals.

Safety data for noradrenaline tartrate in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Norepinephrine is often preferred over agents such as dopamine or phenylephrine because it provides both alpha‑1 mediated vasoconstriction and beta‑1 cardiac stimulation, offering balanced support of blood pressure and cardiac output. Its profile generally results in fewer arrhythmias compared with dopamine, but individual patient factors dictate the optimal choice.

Norepinephrine Basi should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

The drug is supplied as an injectable solution for intravenous use. It is typically administered via a central venous catheter as a continuous infusion, with the rate adjusted according to real‑time blood pressure measurements and clinical response.

Serious risks include myocardial ischemia, severe hypertension, tissue necrosis at the infusion site due to extravasation, life‑threatening arrhythmias, pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of cardiovascular status is essential to detect and manage these complications promptly.

Norepinephrine Basi is contraindicated in patients with known hypersensitivity to noradrenaline or any excipients in the formulation. Caution is advised in individuals with severe peripheral vascular disease, uncontrolled hypertension, or those receiving MAO inhibitors, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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