Product image of Norepinephrine Hameln (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Hameln

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Hameln (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Norepinephrine Hameln, is an adrenergic agonist presented as an injectable solution for intravenous administration. It is employed to raise blood pressure and improve cardiac output in patients experiencing severe hypotension, septic shock, or cardiogenic shock, typically in intensive care settings.

GNH India supplies Norepinephrine Hameln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. All batches are manufactured under EU GMP guidelines and undergo rigorous quality testing before release.

Manufacturer / TM Owner

Hameln Pharma Gmbh

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Indications & Clinical Uses

  • Norepinephrine Hameln is used as a vasopressor to support circulatory function in critical care.
  • Hypotension: Restores arterial pressure and organ perfusion in patients with acute low blood pressure.
  • Septic shock: Increases systemic vascular resistance to improve blood pressure and tissue perfusion during severe infection.
  • Cardiogenic shock: Enhances cardiac output and maintains coronary perfusion in patients with pump failure.

How It Works

  • Noradrenaline Tartrate acts as a direct agonist at α1‑adrenergic receptors causing peripheral vasoconstriction and at β1‑adrenergic receptors increasing myocardial contractility and heart rate. The combined α‑ and β‑stimulation raises systemic vascular resistance and cardiac output, thereby elevating arterial blood pressure in patients with shock.

Side Effects

Norepinephrine Hameln may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tachycardia
  • Arrhythmia
  • Headache
  • Nausea
  • Peripheral ischemia

Serious or Rare Side Effects

  • Severe hypertension
  • Myocardial ischemia
  • Tissue necrosis at extravasation site
  • Pulmonary edema

Precautions & Warnings

  • When using Norepinephrine Hameln, clinicians should observe several safety measures to minimize risks.
  • Blood pressure monitoring: Continuously assess arterial pressure to titrate infusion.
  • Cardiac rhythm monitoring: Observe for arrhythmias, especially in patients with pre‑existing heart disease.
  • Extravasation risk: Administer via a central venous catheter and stop infusion immediately if infiltration occurs.
  • Dose titration: Adjust infusion slowly to avoid abrupt changes in hemodynamics.
  • Use with caution in myocardial ischemia: Reduced coronary perfusion may worsen injury.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine Hameln can interact with other agents that affect the sympathetic nervous system or vascular tone.

Major Interactions (Avoid)

  • MAO inhibitors: Potentiate vasoconstrictive effects, risking severe hypertension.
  • β‑blockers: May blunt the intended increase in heart rate and cardiac output.
  • Tricyclic antidepressants: Enhance norepinephrine activity, increasing risk of hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): May counteract pressor effect, requiring dose adjustments.
  • ACE inhibitors: Can augment hypotensive episodes if norepinephrine is tapered abruptly.
  • Diuretics: May affect intravascular volume, influencing response to the drug.
  • Calcium channel blockers: May have additive effects on blood pressure control.

Frequently Asked Questions

Norepinephrine Hameln is an intravenous vasopressor indicated for the rapid restoration of blood pressure in patients with acute hypotension, septic shock, or cardiogenic shock, helping to maintain vital organ perfusion in critical care settings.

Noradrenaline Tartrate directly stimulates α1‑adrenergic receptors, causing peripheral vasoconstriction, and β1‑adrenergic receptors, increasing heart contractility and rate. This dual action raises systemic vascular resistance and cardiac output, thereby elevating arterial pressure.

Dosing of Norepinephrine Hameln is individualized; the prescribing clinician determines the infusion rate based on the patient’s hemodynamic response, target blood pressure, and clinical condition. No fixed regimen is provided here.

The pregnancy safety category for Noradrenaline Tartrate is unknown. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Compared with agents such as dopamine or epinephrine, norepinephrine provides a stronger α‑adrenergic vasoconstrictive effect with less tachycardia, making it the preferred first‑line pressor for many shock states. Choice of agent depends on the clinical scenario and physician judgment.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. Prior to use, inspect the vial for particulate matter and ensure the solution remains clear.

Norepinephrine Hameln is given as an intravenous infusion, usually through a central venous catheter. The solution is diluted in compatible IV fluids and titrated to achieve the desired blood pressure, with continuous hemodynamic monitoring.

Serious risks include severe hypertension, myocardial ischemia, tissue necrosis from extravasation, and pulmonary edema. Prompt recognition and management of these events are essential, especially during rapid dose adjustments.

Patients with known hypersensitivity to noradrenaline or any formulation component, uncontrolled hypertension, or certain severe cardiac conditions (e.g., unstable angina) should avoid this medication unless a clinician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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