Product image of Norepinephrine Kabi (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Kabi (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Norepinephrine Kabi, is a vasopressor presented as a solution for injection for intravenous use. It treats acute hypotension, septic shock, and cardiac arrest in critical care settings.

GNH India supplies Norepinephrine Kabi as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Norepinephrine Kabi acts on the adrenergic system to restore circulatory stability in severe cardiovascular emergencies.
  • Hypotension: restores vascular tone and raises blood pressure in patients with acute low blood pressure.
  • Septic shock: supports hemodynamics by increasing systemic vascular resistance in septic patients.
  • Cardiac arrest: provides circulatory support during resuscitation efforts.

How It Works

  • Noradrenaline tartrate is a direct agonist of alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors causes peripheral vasoconstriction, while beta‑1 activation increases heart rate and myocardial contractility, together raising systemic vascular resistance and cardiac output to improve blood pressure.

Side Effects

Norepinephrine Kabi may be associated with a range of adverse reactions.

Common Side Effects

  • Headache
  • Tremor
  • Palpitations
  • Nausea

Serious or Rare Side Effects

  • Severe hypertension
  • Cardiac arrhythmia
  • Myocardial ischemia
  • Peripheral ischemia

Precautions & Warnings

  • When using Norepinephrine Kabi, careful monitoring and specific safety measures are required.
  • Dose titration: adjust infusion rate to achieve target arterial pressure.
  • Cardiovascular monitoring: continuous ECG and invasive blood pressure monitoring are essential.
  • Extravasation risk: avoid infiltration and inspect the IV site frequently.
  • Concomitant MAO inhibitors: may potentiate pressor response, requiring heightened vigilance.
  • Pregnancy: use only if the potential benefit justifies the potential risk (category unknown).
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine Kabi can interact with several drug classes, influencing its pressor effect.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt beta‑1 mediated cardiac effects.
  • Tricyclic antidepressants: additive increase in blood pressure.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin, nitroprusside): may require higher norepinephrine doses.
  • Calcium channel blockers: can modify vascular response.
  • Diuretics: may affect intravascular volume and pressor requirements.

Frequently Asked Questions

Norepinephrine Kabi is used in acute care to raise blood pressure and improve circulation in patients with severe hypotension, septic shock, or cardiac arrest. It is administered intravenously by trained clinicians to stabilize hemodynamics during critical events.

Noradrenaline tartrate acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Alpha‑1 activation causes peripheral vasoconstriction, while beta‑1 stimulation increases heart rate and contractility, together elevating systemic vascular resistance and cardiac output to raise arterial pressure.

The dose of Norepinephrine Kabi is individualized. A prescriber determines the infusion rate based on the patient’s blood pressure response, clinical condition, and monitoring data, and then adjusts the infusion to maintain the desired hemodynamic target.

The pregnancy category for noradrenaline tartrate is unknown. It should only be used during pregnancy or lactation when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

The primary alternatives are dopamine and phenylephrine. Norepinephrine provides stronger alpha‑1 mediated vasoconstriction with less tachycardia than dopamine, and offers combined alpha‑ and beta‑1 activity, whereas phenylephrine is a pure alpha‑1 agonist and may cause more pronounced reflex bradycardia.

Norepinephrine Kabi should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. The solution should be kept in its original container until use and inspected for particulate matter before administration.

The product is supplied as a sterile solution for injection and is given by continuous intravenous infusion. It is typically diluted in a compatible carrier fluid and administered through a calibrated infusion pump, with the rate adjusted to achieve the target blood pressure.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, and peripheral ischemia due to excessive vasoconstriction. Continuous cardiovascular monitoring is essential to detect these events promptly and adjust therapy as needed.

Patients with known hypersensitivity to noradrenaline or any excipients, those with uncontrolled hypertension, or individuals in whom excessive vasoconstriction could compromise tissue perfusion should not receive Norepinephrine Kabi. Contraindications are determined by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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