Product image of Norepinephrine Kabi (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Kabi (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Norepinephrine Kabi, is a vasopressor presented as a sterile injectable solution for intravenous use. It is employed to raise blood pressure in critically ill patients experiencing acute hypotension, septic shock, or cardiac arrest.

GNH India supplies Norepinephrine Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi S.R.O.

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Indications & Clinical Uses

  • Norepinephrine Kabi is used in cardiovascular emergencies where rapid blood‑pressure support is required.
  • Acute hypotension: restores systemic vascular resistance to maintain organ perfusion.
  • Septic shock: counteracts vasodilatory shock to improve mean arterial pressure.
  • Cardiac arrest: provides immediate vasoconstriction and inotropic support during resuscitation.

How It Works

  • Norepinephrine acts as a direct agonist at alpha‑1 adrenergic receptors, producing peripheral vasoconstriction, and at beta‑1 receptors, increasing heart‑rate and contractility. The combined alpha‑ and beta‑adrenergic stimulation raises systemic vascular resistance and cardiac output, thereby elevating arterial pressure in shock states.

Side Effects

Adverse reactions may occur with intravenous norepinephrine administration.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Hypertension: excessive rise in blood pressure.
  • Anxiety or restlessness.
  • Nausea or vomiting.
  • Peripheral ischemia at infusion site.

Serious or Rare Side Effects

  • Myocardial ischemia or infarction.
  • Severe hypertension leading to cerebrovascular bleed.
  • Cardiac arrhythmias, including ventricular tachycardia.
  • Tissue necrosis from extravasation.
  • Pulmonary edema.
  • Anaphylactic or severe allergic reaction.

Precautions & Warnings

  • Norepinephrine requires careful clinical monitoring and specific handling precautions.
  • Monitor blood pressure continuously: adjust infusion to target MAP.
  • Titrate infusion slowly: avoid abrupt changes in vascular tone.
  • Use cardiac monitoring: detect arrhythmias early.
  • Avoid in patients with pheochromocytoma: risk of hypertensive crisis.
  • Caution in myocardial ischemia: may worsen oxygen demand.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine can interact with several drug classes, influencing cardiovascular response.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive sympathomimetic effects.
  • Beta‑blockers: may blunt desired inotropic response.
  • Ergot alkaloids: increased risk of severe vasoconstriction.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive episodes when norepinephrine is weaned.
  • Diuretics: alter intravascular volume, affecting dose requirements.
  • Calcium channel blockers: potential additive effects on vascular tone.

Frequently Asked Questions

Norepinephrine Kabi is indicated for rapid blood‑pressure support in acute hypotension, septic shock, and cardiac arrest. It is administered intravenously to increase vascular tone and cardiac output in critically ill patients.

Noradrenaline Tartrate stimulates alpha‑1 receptors causing vasoconstriction and beta‑1 receptors increasing heart‑rate and contractility. This dual action raises systemic vascular resistance and cardiac output, helping to restore adequate arterial pressure during shock.

The dosing regimen for Norepinephrine Kabi is individualized. A qualified prescriber determines the infusion rate based on the patient’s blood‑pressure response, target mean arterial pressure, and clinical condition.

Safety data for Noradrenaline Tartrate in pregnancy or lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under strict medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Norepinephrine is often preferred over dopamine or phenylephrine because it provides strong alpha‑1 mediated vasoconstriction with modest beta‑1 activity, offering balanced blood‑pressure support with fewer tachyarrhythmic effects. Choice of vasopressor depends on the clinical scenario and physician judgment.

Norepinephrine Kabi must be stored refrigerated at 2‑8 °C, protected from light, and never frozen. The product should be kept in its original container and handled with aseptic technique to maintain sterility.

The drug is supplied as a sterile solution for intravenous infusion. It is typically administered through a central or peripheral IV line using a calibrated infusion pump, with continuous blood‑pressure monitoring to guide titration.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, tissue necrosis from extravasation, and rare anaphylactic reactions. Prompt recognition and management of these events are essential during therapy.

Patients with known hypersensitivity to noradrenaline or any formulation component, uncontrolled pheochromocytoma, or severe peripheral vascular disease at risk for ischemia should not receive Norepinephrine Kabi. Clinical judgment is required for all contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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