Product image of Norepinephrine Noridem (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Noridem

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Noridem (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Norepinephrine Noridem, is a sympathomimetic (alpha‑adrenergic agonist) presented as an injectable solution for intravenous use. Classified as a vasopressor/antihypotensive, it is employed to rapidly increase systemic vascular resistance and cardiac output, thereby raising blood pressure in acute hypotensive states such as septic or cardiogenic shock and during cardiac arrest.

GNH India supplies Norepinephrine Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Norepinephrine Noridem acts on the sympathetic vascular system to counteract severe hypotension.

  • Acute hypotension: restores vascular tone and raises systemic blood pressure.
  • Septic shock: improves perfusion pressure and supports organ function.
  • Cardiogenic shock: enhances cardiac output while maintaining coronary perfusion.
  • Cardiac arrest: provides essential vasoconstriction as part of advanced life support protocols.

How It Works

  • Norepinephrine Noridem (noradrenaline tartrate) exerts its effect by directly stimulating alpha‑1 adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction, and by activating beta‑1 receptors in the heart, which increases heart rate and contractility. The combined alpha‑1 and beta‑1 activity elevates systemic vascular resistance and cardiac output, rapidly correcting low arterial pressure in emergency settings.

Side Effects

Norepinephrine may be associated with a range of adverse reactions, varying from common to serious.

Common Side Effects

  • Headache
  • Tachycardia
  • Peripheral ischemia or cold extremities
  • Anxiety or restlessness
  • Nausea or vomiting

Serious or Rare Side Effects

  • Severe hypertension
  • Myocardial ischemia or infarction
  • Cardiac arrhythmias
  • Tissue necrosis at extravasation sites
  • Pulmonary edema

Precautions & Warnings

When using Norepinephrine Noridem, careful monitoring and specific precautions are essential to ensure safety.

  • Monitor blood pressure continuously: adjust infusion rate to maintain target MAP.
  • Use central venous access when possible: reduces risk of extravasation.
  • Assess cardiac function regularly: watch for tachyarrhythmias or ischemia.
  • Avoid rapid bolus administration: infuse gradually to prevent sudden hypertension.
  • Limit use in patients with uncontrolled hypertension: may exacerbate condition.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine can interact with several medications, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: may cause excessive hypertension.
  • Other vasopressors (e.g., phenylephrine): additive pressor effects leading to severe hypertension.
  • Beta‑blockers: can blunt beta‑1 mediated cardiac effects, altering response.

Moderate Interactions (Monitor Closely)

  • Tricyclic antidepressants: increase risk of hypertension.
  • Vasodilators (e.g., nitroglycerin): may reduce pressor effectiveness.
  • Anesthetics (e.g., halothane): can potentiate cardiovascular instability.

Frequently Asked Questions

Norepinephrine Noridem is used as a vasopressor to rapidly increase blood pressure in emergency situations such as acute hypotension, septic shock, cardiogenic shock, and during cardiac arrest as part of advanced life support protocols.

Noradrenaline tartrate directly stimulates alpha‑1 adrenergic receptors causing vasoconstriction and beta‑1 receptors in the heart, which increase heart rate and contractility. This dual action raises systemic vascular resistance and cardiac output, quickly correcting low arterial pressure.

The dose of Norepinephrine Noridem is individualized. A qualified prescriber determines the infusion rate based on the patient’s blood pressure response, clinical condition, and therapeutic goals, following local guidelines and monitoring protocols.

Safety data for Norepinephrine Noridem in pregnancy or lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Norepinephrine is often preferred for its balanced alpha‑1 and beta‑1 activity, providing both vasoconstriction and modest cardiac stimulation. Compared with pure alpha agonists like phenylephrine, it better supports cardiac output, while it may cause fewer tachyarrhythmias than dopamine in similar settings.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Norepinephrine Noridem is supplied as an injectable solution for intravenous infusion. It is typically administered through a controlled infusion pump, often via a central venous catheter, with continuous blood pressure monitoring to titrate the dose.

Serious risks include severe hypertension, myocardial ischemia or infarction, life‑threatening arrhythmias, tissue necrosis from extravasation, and pulmonary edema. Prompt recognition and management of these events are critical.

Patients with known hypersensitivity to noradrenaline or any formulation component should avoid it. It is also contraindicated in uncontrolled hypertension and should be used with extreme caution in patients with severe peripheral vascular disease or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.