Product image of Norepinephrine Sopharma (Noradrenaline Tartrate) supplied by GNH India

Norepinephrine Sopharma

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Norepinephrine Sopharma (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Norepinephrine Sopharma, is a sympathomimetic amine presented as an intravenous solution for use in acute care settings. It acts as a potent vasopressor to raise blood pressure in patients with severe hypotension, such as those experiencing septic or cardiogenic shock.

GNH India supplies Norepinephrine Sopharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to health‑care institutions across multiple regions and ensures timely delivery.

Manufacturer / TM Owner

Sopharma Warszawa Sp. Z O.O.

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Indications & Clinical Uses

  • Norepinephrine is a vasopressor used in critical care to manage life‑threatening hypotension.
  • Septic shock: restores arterial pressure and improves organ perfusion.
  • Cardiogenic shock: supports cardiac output while maintaining systemic vascular resistance.
  • Post‑operative hypotension: stabilizes blood pressure during anesthesia emergence.

How It Works

  • Norepinephrine acts as a direct agonist at α1‑adrenergic receptors, causing peripheral vasoconstriction, and at β1‑adrenergic receptors, increasing myocardial contractility and heart rate. The combined α‑ and β‑stimulating effects raise systemic vascular resistance and cardiac output, rapidly elevating arterial blood pressure in patients with acute circulatory failure. These actions are dose‑dependent and are titrated to achieve target mean arterial pressure while monitoring for adverse cardiovascular responses.

Side Effects

Norepinephrine may produce a range of adverse reactions, varying from frequent to rare but serious.

Common Side Effects

  • Tachycardia: increased heart rate due to β1 stimulation.
  • Hypertension: excessive rise in blood pressure from α1 vasoconstriction.
  • Headache: vascular changes may trigger cranial discomfort.
  • Anxiety or restlessness: central adrenergic activation.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary perfusion from high afterload.
  • Severe arrhythmias: ventricular tachycardia or fibrillation.
  • Peripheral tissue necrosis: extravasation at infusion site causing ischemic injury.

Precautions & Warnings

When using norepinephrine, clinicians should observe specific safety measures to minimize risks.

  • Blood pressure monitoring: continuously assess arterial pressure and adjust infusion rate.
  • Cardiac rhythm surveillance: watch for tachyarrhythmias and ischemic changes.
  • Dose titration: start low and increase gradually to reach target mean arterial pressure.
  • Contraindications: avoid in patients with pheochromocytoma or uncontrolled hypertension.
  • Caution in myocardial ischemia: use only if benefits outweigh risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine can interact with other agents, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effects.
  • Ergot alkaloids: severe vasospasm.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt β1 effects, requiring higher doses.
  • Other vasopressors (e.g., phenylephrine): combined pressor effect may cause excessive hypertension.
  • Calcium channel blockers: may affect vascular tone and require monitoring.

Frequently Asked Questions

Norepinephrine Sopharma is an intravenous vasopressor indicated for the rapid restoration of blood pressure in patients with severe hypotension, such as those experiencing septic shock, cardiogenic shock, or postoperative hypotension in critical care settings.

Noradrenaline Tartrate directly stimulates α1‑adrenergic receptors, causing peripheral vasoconstriction, and β1‑adrenergic receptors, increasing heart contractility and rate. The combined effect raises systemic vascular resistance and cardiac output, quickly elevating arterial pressure.

The dosage of Norepinephrine Sopharma is individualized. A qualified prescriber determines the infusion rate based on the patient’s hemodynamic status, target mean arterial pressure, and response to therapy, following institutional protocols.

The safety of Norepinephrine Sopharma during pregnancy or lactation has not been established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Norepinephrine is often preferred over agents such as phenylephrine because it provides both α‑mediated vasoconstriction and β1‑mediated cardiac support, offering a balanced increase in blood pressure and cardiac output. Other vasopressors may lack this combined effect, influencing the choice based on clinical scenario.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Maintain the cold‑chain during transport and keep the solution in its original packaging until use.

Norepinephrine Sopharma is given as an intravenous infusion, typically via a central venous catheter. The infusion is titrated to achieve the desired blood pressure, with continuous hemodynamic monitoring throughout the administration.

Serious risks include myocardial ischemia, severe arrhythmias such as ventricular tachycardia or fibrillation, and peripheral tissue necrosis if the drug extravasates from the vein. Prompt recognition and management of these events are essential.

Patients with known hypersensitivity to noradrenaline, uncontrolled hypertension, pheochromocytoma, or severe peripheral vascular disease should not receive Norepinephrine Sopharma unless the clinical benefit outweighs the risk and close monitoring is possible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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