Product image of Norfloxacin 1 A Pharma (Norfloxacin) supplied by GNH India

Norfloxacin 1 A Pharma

Active Ingredient:
Norfloxacin
Origin:
EU

Norfloxacin 1 A Pharma (Norfloxacin)

Norfloxacin, the active ingredient in Norfloxacin 1 A Pharma, is a fluoroquinolone presented as a tablet for oral use. It treats bacterial infections of the urinary, prostate, gastrointestinal and respiratory tracts in adults.
GNH India supplies Norfloxacin 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Norfloxacin is an antibacterial agent used to manage infections caused by susceptible bacteria in several organ systems.

  • Urinary tract infections: effective in treating uncomplicated UTIs caused by susceptible pathogens.
  • Prostatitis: helps eradicate bacterial infection of the prostate gland.
  • Gastrointestinal infections: used for bacterial dysentery and travel‑related diarrhoea.
  • Respiratory tract infections: treats acute bacterial bronchitis and sinusitis when indicated.

How It Works

  • Norfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and relaxation of bacterial DNA, leading to inhibition of bacterial cell division and ultimately bacterial cell death.

Side Effects

Norfloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhoea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Rash: mild skin eruptions.
  • Photosensitivity: increased sensitivity to sunlight.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, may occur without warning.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Clostridioides difficile infection: severe colitis.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Hepatotoxicity: liver enzyme elevations or injury.

Precautions & Warnings

Before prescribing Norfloxacin, consider patient‑specific factors and safety measures.

  • Renal impairment: dose adjustment may be required.
  • History of tendon disorders: avoid use due to increased rupture risk.
  • Concurrent antacids or mineral supplements: separate administration by at least 2 hours.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Known hypersensitivity to fluoroquinolones: contraindicated.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Norfloxacin can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Theophylline: increased serum concentrations leading to toxicity.
  • Warfarin: potentiated anticoagulant effect, monitor INR closely.
  • Corticosteroids: heightened risk of tendon rupture.

Moderate Interactions (Monitor Closely)

  • Antacids or zinc/calcium supplements: may reduce Norfloxacin absorption.
  • NSAIDs: may increase risk of central nervous system stimulation.
  • Diabetes medications: possible alteration of glucose control.

Frequently Asked Questions

Norfloxacin 1 A Pharma is indicated for bacterial infections of the urinary tract, prostate, gastrointestinal system and respiratory tract. It is prescribed when the causative organisms are known or suspected to be susceptible to fluoroquinolone antibiotics.

Norfloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial cell death.

The dosage of Norfloxacin 1 A Pharma is determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. Patients should follow the prescriber’s instructions and the label directions.

The safety of Norfloxacin in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Norfloxacin shares the same class mechanism as other fluoroquinolones but differs in its spectrum of activity and pharmacokinetic profile. It is often chosen for urinary and gastrointestinal infections where susceptibility data favor Norfloxacin over alternatives such as ciprofloxacin or levofloxacin.

Store the product at ambient temperature, below 25 °C, in the original packaging. Protect it from moisture, excessive heat and direct sunlight to maintain stability and potency.

Norfloxacin 1 A Pharma is taken orally, usually with a full glass of water. It may be taken with or without food, but if antacids or mineral supplements are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture, especially in the Achilles tendon, QT interval prolongation leading to cardiac arrhythmias, peripheral neuropathy, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if these events occur.

Patients with a known hypersensitivity to Norfloxacin or any fluoroquinolone should avoid the drug. It is also contraindicated in individuals with a history of tendon disorders related to fluoroquinolone use, and it should be used with caution in patients with significant renal impairment or cardiac conduction abnormalities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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