Product image of Norfloxacină Atb (Norfloxacin) supplied by GNH India

Norfloxacină Atb

Active Ingredient:
Norfloxacin
Origin:
EU

Norfloxacină Atb (Norfloxacin)

Norfloxacin, the active ingredient in Norfloxacină Atb, is a fluoroquinolone presented as a tablet for oral use. It is employed to treat bacterial infections of the urinary tract, prostate and gastrointestinal tract, and is indicated for uncomplicated infections in otherwise healthy adults.

GNH India supplies Norfloxacină Atb as a licensed, GDP‑compliant international pharmaceutical product to hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable delivery across multiple markets. The company adheres to WHO‑GMP standards and provides full regulatory documentation for importers.

Manufacturer / TM Owner

Antibiotice Sa

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Indications & Clinical Uses

Norfloxacin is a fluoroquinolone antibacterial indicated for infections of specific organ systems.

  • Urinary tract infections: effective in eradicating susceptible Gram‑negative and some Gram‑positive bacteria, relieving symptoms and preventing recurrence.
  • Prostatitis: achieves bacterial clearance in the prostate tissue, reducing inflammation and clinical signs.
  • Gastrointestinal infections: treats susceptible enteric pathogens, aiding resolution of diarrhoea and abdominal discomfort.

How It Works

  • Norfloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to the enzyme‑DNA complex, it prevents the resealing of DNA strands after cleavage, leading to inhibition of DNA synthesis, transcription and ultimately bacterial cell death. Its activity is concentration‑dependent and covers a broad range of Gram‑negative and some Gram‑positive organisms.

Side Effects

Norfloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often transient.
  • Diarrhoea: loose stools that may be self‑limiting.
  • Headache: mild to moderate intensity.
  • Dizziness: sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain or swelling, especially in the Achilles.
  • Peripheral neuropathy: tingling, numbness or burning sensations.
  • QT prolongation: cardiac rhythm changes detectable on ECG.
  • Severe allergic reactions: anaphylaxis, angioedema, or bronchospasm.
  • Clostridioides difficile colitis: persistent diarrhoea with abdominal pain.

Precautions & Warnings

Before prescribing norfloxacin, clinicians should consider several safety and handling precautions.

  • Renal impairment: adjust therapy or monitor renal function closely.
  • History of tendon disorders: avoid use in patients with prior tendon injury.
  • Concomitant QT‑prolonging drugs: assess risk of cardiac arrhythmias.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Age >65 years: increased susceptibility to CNS effects; monitor closely.
  • Store at below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Norfloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminium or magnesium: reduce absorption; separate dosing by at least 2 hours.
  • Warfarin: may enhance anticoagulant effect; monitor INR closely.
  • Cyclosporine: increased risk of nephrotoxicity; consider alternative therapy.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of CNS stimulation.
  • Theophylline: potential for increased serum levels; monitor for toxicity.
  • Oral corticosteroids: may raise risk of tendon rupture; advise caution.

Frequently Asked Questions

Norfloxacină Atb is prescribed for bacterial infections of the urinary tract, prostatitis and certain gastrointestinal infections. It targets susceptible Gram‑negative and some Gram‑positive organisms, helping to clear the infection and alleviate related symptoms in adult patients.

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing the resealing of DNA strands after cleavage, it stops bacterial cell division and leads to bacterial death, providing a bactericidal effect.

The exact dose and duration are set by the prescribing clinician based on the type and severity of the infection, patient age, renal function and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for norfloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To request Norfloxacină Atb, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Norfloxacin shares the class‑wide mechanism of DNA gyrase inhibition but differs in its spectrum of activity and pharmacokinetic profile. Compared with agents such as ciprofloxacin, norfloxacin has slightly lower activity against some Gram‑positive organisms but is similarly effective for many urinary and gastrointestinal pathogens.

Store the tablets at temperatures below 25 °C in the original packaging. Keep them away from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

Norfloxacină Atb is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed. Dosing times and any required separation from antacids or supplements are determined by the prescriber.

Serious adverse events include tendon rupture, peripheral neuropathy, QT‑interval prolongation and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden joint pain, numbness, palpitations, or signs of a severe allergic response.

Norfloxacin is contraindicated in patients with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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