Product image of Norfloxacina Abc (Norfloxacin) supplied by GNH India

Norfloxacina Abc

Active Ingredient:
Norfloxacin
Origin:
EU

Norfloxacina Abc (Norfloxacin)

Norfloxacin, the active ingredient in Norfloxacina Abc, is a fluoroquinolone antibiotic presented as an oral tablet for oral administration. It is used to treat a range of bacterial infections, including urinary tract infections, prostatitis, gastrointestinal infections and respiratory tract infections, primarily in adult patients requiring systemic therapy. The drug exerts its antibacterial effect by inhibiting key bacterial enzymes involved in DNA replication, providing a broad spectrum of activity against Gram‑negative and some Gram‑positive organisms.

GNH India supplies Norfloxacina Abc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abc Farmaceutici S.P.A.

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Indications & Clinical Uses

Norfloxacina Abc (norfloxacin) is indicated for bacterial infections affecting several organ systems.

  • Urinary tract infections: effective in eradicating susceptible uropathogens and relieving urinary symptoms.
  • Prostatitis: helps eliminate the causative bacteria and reduces prostatic inflammation.
  • Gastrointestinal infections: treats susceptible enteric pathogens causing dysentery or colitis.
  • Respiratory tract infections: combats common bacterial agents responsible for bronchitis and pneumonia.

How It Works

  • Norfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, the drug prevents bacterial DNA synthesis and transcription, leading to cell death. This mechanism provides bactericidal activity against a broad range of Gram‑negative and some Gram‑positive organisms.

Side Effects

Norfloxacina Abc may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: feeling light‑headed or unsteady.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Rash: mild skin redness or itching.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • Peripheral neuropathy: tingling, numbness, or burning sensations in extremities.
  • QT interval prolongation: potential cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, swelling of face or throat.
  • Clostridioides difficile infection: severe colitis after antibiotic use.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Norfloxacina Abc, clinicians should consider several safety aspects.

  • Renal function: adjust dose in patients with severe renal impairment.
  • Age: use cautiously in elderly patients due to increased risk of tendon injury.
  • Concomitant QT‑prolonging drugs: monitor cardiac rhythm and avoid combined use when possible.
  • History of hypersensitivity: avoid in individuals with known allergy to fluoroquinolones.
  • Pregnancy and lactation: avoid unless clearly needed, as safety data are limited.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Norfloxacina Abc can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce norfloxacin absorption.
  • Warfarin: may increase anticoagulant effect and risk of bleeding.
  • CYP450 inducers (e.g., rifampicin): may lower plasma concentrations of norfloxacin.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs: increased risk of central nervous system effects.
  • Theophylline: may raise serum theophylline levels, requiring monitoring.
  • Corticosteroids: heightened risk of tendon rupture when used together.

Frequently Asked Questions

Norfloxacina Abc contains the fluoroquinolone norfloxacin and is prescribed to treat bacterial infections such as urinary tract infections, prostatitis, certain gastrointestinal infections and respiratory tract infections caused by susceptible organisms.

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication. This inhibition stops bacterial DNA synthesis, leading to bacterial cell death and resolution of the infection.

The appropriate dose of Norfloxacina Abc is determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for norfloxacin during pregnancy and lactation are limited. It is generally avoided unless the potential benefit outweighs the risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their doctor.

To request Norfloxacina Abc, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Norfloxacina Abc (norfloxacin) shares the class‑wide mechanism of DNA gyrase inhibition with other fluoroquinolones such as ciprofloxacin. Compared with ciprofloxacin, norfloxacin has a similar spectrum but may differ in pharmacokinetic properties, dosing frequency and tissue penetration, influencing the choice of agent based on infection site and patient factors.

Store Norfloxacina Abc tablets at temperatures below 25 °C, in the original container, protected from moisture and direct light. Keep out of reach of children and do not use after the expiry date printed on the packaging.

Norfloxacina Abc is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid simultaneous intake of antacids or supplements containing calcium, magnesium or iron, as these may reduce absorption.

Serious adverse events include tendon rupture (especially Achilles), peripheral neuropathy, QT‑interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and hepatic dysfunction. Patients should seek immediate medical attention if they experience sudden tendon pain, numbness, palpitations or severe skin reactions.

Individuals with a known hypersensitivity to norfloxacin, other fluoroquinolones, or any component of the formulation should avoid the product. It is also contraindicated in patients with a history of tendon disorders related to fluoroquinolone use, and should be used with caution in those with significant cardiac arrhythmias or uncontrolled epilepsy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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