Norfloxacino Cinfa (Norfloxacin)

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial cell division and leads to bacterial death.

The prescribed dose is determined by the treating physician based on the type and severity of infection, patient weight, renal function and local guidelines. Typical adult regimens range from 200 mg twice daily to 400 mg once daily, but exact dosing must be individualized.

Safety data are limited; the pregnancy category is unknown. Norfloxacin is generally avoided in pregnancy and lactation unless the potential benefit outweighs the risk, and only under medical supervision.

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Norfloxacin shares the class‑wide mechanism of DNA gyrase inhibition but has a slightly different spectrum, offering strong activity against many Gram‑negative pathogens and limited Gram‑positive coverage. Compared with ciprofloxacin, it may be less potent against Pseudomonas aeruginosa but is similarly effective for uncomplicated urinary and gastrointestinal infections.

Store tablets at temperatures below 25 °C in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date printed on the package.

The medication is taken orally with a full glass of water. It may be taken with or without food, but patients should avoid taking antacids or supplements containing magnesium, aluminum, calcium or iron within two hours of the dose to ensure optimal absorption.

Serious adverse events include tendon rupture or tendinitis, especially in the Achilles tendon, QT interval prolongation leading to cardiac arrhythmias, and severe hypersensitivity reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, or signs of an allergic reaction.

Individuals with a known hypersensitivity to norfloxacin or any fluoroquinolone should avoid the product. It is also contraindicated in patients taking certain interacting drugs (e.g., strong antacids, warfarin, theophylline) without careful monitoring, and it should be used with caution or avoided in pregnant or lactating women, children, and patients with a history of tendon disorders.