Product image of Norgesic (Orphenadrine Citrate, Paracetamol) supplied by GNH India

Norgesic

Active Ingredient:
Orphenadrine Citrate, Paracetamol
Origin:
EU

Norgesic (Orphenadrine Citrate, Paracetamol)

Orphenadrine citrate and paracetamol, the active ingredients in Norgesic, are a muscle relaxant and analgesic presented as tablets for oral use. They treat muscle spasm and associated pain in adults.\nGNH India supplies Norgesic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Aps

1
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Indications & Clinical Uses

  • Norgesic combines a centrally acting muscle relaxant with an analgesic to address conditions involving muscle spasm and pain.\n\nMuscle spasm: provides relief of involuntary muscle contraction and associated discomfort.\nMusculoskeletal pain: reduces pain arising from joints, ligaments and soft tissues.\nBack pain: alleviates acute low‑back pain episodes.\nAcute pain: manages short‑term pain following injury or surgery.

How It Works

  • Orphenadrine citrate acts as a centrally acting anticholinergic, blocking muscarinic receptors to reduce skeletal muscle hyperactivity, while paracetamol exerts analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, decreasing prostaglandin synthesis in the CNS.

Side Effects

  • Common Side Effects:\n- Drowsiness: feeling of sleepiness or reduced alertness.\n- Dry mouth: decreased salivation leading to a dry oral cavity.\n- Dizziness: sensation of light‑headedness or unsteadiness.\n- Blurred vision: temporary loss of visual sharpness.\n- Nausea: feeling of queasiness or urge to vomit.\n- Constipation: reduced bowel movements or hard stools.\n\nSerious or Rare Side Effects:\n- Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.\n- Hepatotoxicity: liver injury indicated by elevated enzymes or jaundice.\n- Cardiac arrhythmia: abnormal heart rhythms, especially in predisposed patients.\n- Urinary retention: difficulty emptying the bladder.\n- Anaphylaxis: rapid, severe allergic reaction with airway compromise.\n- Blood dyscrasias: abnormal blood cell counts including agranulocytosis.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.\n\nLiver function assessment: evaluate hepatic status due to paracetamol metabolism.\nGlaucoma caution: avoid in patients with narrow‑angle glaucoma because of anticholinergic effects.\nConcomitant CNS depressants: monitor for enhanced sedation when combined with alcohol or other sedatives.\nUrinary retention risk: be vigilant in patients with prostatic hypertrophy or bladder outlet obstruction.\nAlcohol use: limit intake as it may increase hepatotoxic potential.\nStore at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Norgesic may interact with several medicines; review the following categories.\n\nMajor Interactions (Avoid):\n- MAO inhibitors: risk of hypertensive crisis when combined.\n- Other anticholinergics: additive anticholinergic burden leading to severe dry mouth, constipation, or confusion.\n- Hepatotoxic drugs (e.g., isoniazid, methotrexate): increased risk of liver injury.\n- Alcohol: potentiates sedation and liver toxicity.\n- CNS depressants (opioids, benzodiazepines): enhanced central nervous system depression.\n\nModerate Interactions (Monitor Closely):\n- CYP450 inhibitors (e.g., fluconazole): may raise paracetamol plasma levels.\n- CYP450 inducers (e.g., rifampicin): may reduce therapeutic effect.\n- Warfarin: possible increase in bleeding tendency.\n- Antihypertensives: additive hypotensive effect.\n- Diuretics: may exacerbate urinary retention.

Frequently Asked Questions

Norgesic is prescribed to relieve muscle spasm and associated pain, including musculoskeletal discomfort, acute back pain, and short‑term pain episodes following injury or surgery.

Orphenadrine citrate acts as a centrally acting anticholinergic muscle relaxant by blocking muscarinic receptors in the central nervous system, which reduces skeletal muscle hyperactivity and spasm.

The specific dose and dosing schedule of Norgesic are determined by the prescribing healthcare professional based on the patient’s condition, age, and response to therapy.

Safety data for Norgesic in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Norgesic combines an anticholinergic muscle relaxant (orphenadrine) with an analgesic (paracetamol), offering both spasm relief and pain control, whereas many other muscle relaxants provide only spasm reduction without an added analgesic component.

Store Norgesic tablets at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight to maintain stability.

Norgesic is taken orally as a tablet, usually with a glass of water. The exact timing relative to meals should follow the prescribing clinician’s instructions.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity leading to liver injury, cardiac arrhythmias, urinary retention, and rare cases of anaphylaxis.

Norgesic should be avoided in patients with known hypersensitivity to orphenadrine, paracetamol, or any excipients, as well as in individuals with severe hepatic impairment, narrow‑angle glaucoma, or uncontrolled urinary retention.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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