Product image of Norgesic (Orphenadrine Citrate, Paracetamol) supplied by GNH India

Norgesic

Active Ingredient:
Orphenadrine Citrate, Paracetamol
Origin:
EU

Norgesic (Orphenadrine Citrate, Paracetamol)

Orphenadrine citrate, the active ingredient in Norgesic, is a muscle relaxant presented as an oral tablet formulation for oral use. It treats acute musculoskeletal pain and muscle spasm in adults. GNH India supplies Norgesic as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

  • Norgesic, containing orphenadrine citrate and paracetamol, is used to manage acute musculoskeletal pain and muscle spasm.
  • Acute musculoskeletal pain: provides analgesic relief and reduces muscle spasm.
  • Back pain: alleviates pain and improves mobility.
  • Muscle spasm associated with injury: relaxes skeletal muscle and reduces discomfort.

How It Works

  • Orphenadrine citrate acts as a centrally acting anticholinergic muscle relaxant by blocking muscarinic receptors, decreasing CNS excitability and reducing muscle spasm. Paracetamol exerts analgesic and antipyretic effects primarily through inhibition of cyclooxygenase enzymes in the central nervous system, lowering prostaglandin synthesis and modulating pain pathways. The combined actions deliver both muscle relaxation and pain relief.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Hepatotoxicity
  • Stevens‑Johnson syndrome

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Assess liver function: monitor hepatic enzymes prior to and during treatment.
  • Avoid alcohol: limit consumption to reduce additional liver stress.
  • Use caution in elderly: increased sensitivity to anticholinergic effects.
  • Review concomitant CNS depressants: may enhance sedation.
  • Store at ambient temperature: keep below 25°C, protect from moisture.

Avoid Interactions

Norgesic may interact with other medicines; review the following.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Alcohol: increased hepatotoxic risk.
  • Other hepatotoxic drugs (e.g., isoniazid, methotrexate): additive liver injury.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, opioids): potential for excessive sedation.
  • Warfarin: possible alteration of INR.
  • CYP450 inhibitors (e.g., fluconazole): may raise paracetamol plasma levels.

Frequently Asked Questions

Norgesic is indicated for the relief of acute musculoskeletal pain, such as back pain, and for the reduction of muscle spasm associated with injury. It combines a muscle relaxant with an analgesic to address both pain and spasm in adult patients.

Orphenadrine citrate acts as a centrally acting anticholinergic muscle relaxant. By blocking muscarinic receptors in the central nervous system, it reduces neuronal excitability, leading to decreased muscle tone and relief of spasm.

The appropriate dose of Norgesic is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Norgesic in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their doctor.

To order Norgesic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with agents such as cyclobenzaprine, Norgesic adds paracetamol, offering both muscle relaxation and analgesia in a single tablet. This can simplify regimens but may increase the risk of hepatotoxicity, especially when combined with other paracetamol‑containing products.

Store Norgesic at ambient temperature, preferably below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Norgesic is taken orally, usually with a full glass of water. It should be swallowed whole and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, liver injury (hepatotoxicity), and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, jaundice, difficulty breathing, or swelling.

Norgesic should be avoided in individuals with known hypersensitivity to orphenadrine, paracetamol, or any excipients, as well as in patients with severe liver disease, uncontrolled glaucoma, or those taking MAO inhibitors. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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