Product image of Norgesic (Orphenadrine Citrate, Paracetamol) supplied by GNH India

Norgesic

Active Ingredient:
Orphenadrine Citrate, Paracetamol
Origin:
EU

Norgesic (Orphenadrine Citrate, Paracetamol)

Orphenadrine citrate and paracetamol, the active ingredients in Norgesic, are a central acting muscle relaxant and an analgesic presented as oral tablets for oral use. They are used to relieve muscle‑spasm related pain and associated discomfort in adult patients.

GNH India supplies Norgesic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Ab

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Indications & Clinical Uses

Norgesic combines a muscle relaxant and an analgesic and is indicated for conditions involving musculoskeletal pain and spasm.

  • Acute musculoskeletal pain: reduces pain intensity and improves functional mobility.
  • Muscle spasm due to strains or sprains: relaxes skeletal muscles and eases discomfort.
  • Low back pain: alleviates spasm‑related tension and pain.
  • Post‑traumatic injury pain: provides analgesia while relaxing contracted muscles.

How It Works

  • Orphenadrine citrate acts as an anticholinergic agent and central muscle relaxant, possibly through NMDA‑receptor antagonism, decreasing neuronal excitability in the spinal cord. Paracetamol exerts analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, reducing prostaglandin synthesis within the CNS, which lowers pain perception and fever.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Nausea: mild stomach upset or urge to vomit.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Hepatotoxicity: liver injury, particularly with excessive paracetamol exposure.
  • Cardiac arrhythmia: irregular heartbeat that may require medical attention.

Precautions & Warnings

Before prescribing Norgesic, clinicians should consider several safety aspects.

  • Liver function assessment: evaluate hepatic health due to paracetamol content.
  • Elderly patients: start with lower doses and monitor for increased sedation.
  • Glaucoma or urinary retention: use cautiously as anticholinergic effects may exacerbate these conditions.
  • Alcohol consumption: advise patients to limit alcohol to reduce liver risk.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Norgesic may interact with other medicines; awareness of interaction severity helps guide safe use.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Other anticholinergics: increased anticholinergic burden.
  • CNS depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression.
  • Alcohol: heightened liver toxicity and sedation.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect.
  • Antihypertensive agents: may enhance blood‑pressure lowering.
  • Antihistamines: could increase drowsiness and anticholinergic side effects.

Frequently Asked Questions

Norgesic is a prescription oral tablet that combines orphenadrine citrate, a central muscle relaxant, with paracetamol, an analgesic. It is used to relieve pain and muscle spasm associated with acute musculoskeletal conditions such as strains, sprains, low‑back pain, and post‑traumatic injuries in adult patients.

Orphenadrine citrate acts as an anticholinergic and central muscle relaxant, likely by blocking NMDA receptors and reducing neuronal excitability in the spinal cord. This action helps to relax skeletal muscles and decrease spasm‑related pain.

The specific dose of Norgesic is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Norgesic in pregnancy and lactation are limited. The prescriber should weigh potential benefits against risks, and it is generally recommended to avoid use unless clearly needed. Breastfeeding mothers should consult their doctor before taking the medication.

To order Norgesic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Norgesic combines a muscle relaxant (orphenadrine) with an analgesic (paracetamol), offering both spasm relief and pain control in a single tablet. Compared with single‑ingredient relaxants such as cyclobenzaprine, Norgesic may reduce the need for additional analgesics, but the choice depends on the patient’s specific clinical profile and tolerability.

Norgesic tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect from moisture and direct sunlight, and keep out of reach of children.

Norgesic is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed, unless the prescriber advises otherwise. It is typically taken with or without food as directed by the healthcare provider.

Serious risks include severe allergic reactions (rash, swelling, breathing difficulty), hepatotoxicity from paracetamol overdose, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience any signs of these conditions.

Norgesic should be avoided in patients with known hypersensitivity to orphenadrine, paracetamol, or any excipients, as well as in individuals with severe liver disease, uncontrolled glaucoma, or urinary retention. It is also contraindicated in patients taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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