Normogrip (Chlorphenamine Maleate, Phenylephrine Hydrochloride, Paracetamol)

Normogrip combines an antihistamine, a decongestant and an analgesic to address multiple upper‑respiratory symptoms.

• Allergic rhinitis: reduces sneezing, itching and runny nose.
• Nasal congestion: eases blockage by shrinking swollen nasal vessels.
• Headache: alleviates pain associated with sinus pressure.
• Fever: lowers elevated body temperature.
• Mild pain: provides relief from aches such as sore throat or muscle discomfort.

• Chlorphenamine maleate blocks H1 histamine receptors, preventing the actions of histamine that cause itching and vasodilation. Phenylephrine hydrochloride acts as an α‑adrenergic agonist, inducing vasoconstriction of nasal mucosal vessels and reducing swelling. Paracetamol exerts central COX inhibition, producing analgesic and antipyretic effects by lowering the hypothalamic set‑point for temperature and diminishing pain signalling.

Common Side Effects

• Drowsiness: mild sleepiness or reduced alertness.
• Dry mouth: decreased salivation leading to throat discomfort.
• Dizziness: sensation of light‑headedness.
• Nausea: mild stomach upset.
• Headache: transient head pain.
• Gastrointestinal upset: occasional stomach discomfort.

Serious or Rare Side Effects

• Allergic reactions: rash, itching, swelling of face or throat.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Breathing difficulties: bronchospasm or airway swelling.
• Rapid heartbeat: tachycardia or palpitations.
• Liver enzyme elevation: potential hepatic stress.
• Severe hypotension: marked drop in blood pressure.

Before using Normogrip, consider the following precautions.

• Pregnancy: consult a healthcare professional before use.
• Asthma or chronic respiratory disease: use with caution as phenylephrine may affect breathing.
• Concomitant medications: review all current drugs to avoid interactions.
• Liver disease: monitor paracetamol intake to prevent hepatic overload.
• Age considerations: dosage may need adjustment for children and the elderly.
• Store at below 25°C: keep in the original pack, protect from moisture.

Normogrip may interact with several medicines.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
• Other antihistamines: increased sedation and anticholinergic effects.
• Alcohol: enhanced drowsiness and impaired coordination.

Moderate Interactions (Monitor Closely)

• CYP450 substrates: phenylephrine can alter metabolism of certain drugs.
• Warfarin: paracetamol may increase INR and bleeding risk.
• Selective serotonin reuptake inhibitors (SSRIs): potential for increased bleeding tendency.