Product image of Normotus Antitussive (Dextromethorphan Hydrobromide) supplied by GNH India

Normotus Antitussive

Active Ingredient:
Dextromethorphan Hydrobromide
Origin:
EU

Normotus Antitussive (Dextromethorphan Hydrobromide)

Dextromethorphan, the active ingredient in Normotus Antitussive, is an antitussive presented as an oral formulation for oral use. It provides temporary relief of cough due to minor throat and bronchial irritation in adults and children.

GNH India supplies Normotus Antitussive as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Normon, S.A.

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Indications & Clinical Uses

Dextromethorphan is used to suppress cough associated with irritation of the throat or bronchial passages.

  • Cough due to minor throat irritation: temporary relief of cough symptoms.
  • Cough due to mild bronchial irritation: reduces cough frequency.
  • Occasional dry cough: suppresses the cough reflex.

How It Works

  • Dextromethorphan acts as a sigma‑1 receptor agonist and an NMDA receptor antagonist, which together dampen neuronal activity in the medullary cough center, thereby reducing the cough reflex without affecting respiratory function.

Side Effects

Common Side Effects

  • Drowsiness
  • Nausea
  • Dizziness
  • Dry mouth
  • Mild headache
  • Gastrointestinal discomfort

Serious or Rare Side Effects

  • Allergic reaction (rash, itching, swelling)
  • Hallucinations or vivid dreams
  • Severe dizziness leading to falls
  • Serotonin syndrome in combination with serotonergic drugs
  • Respiratory depression (rare)
  • Cardiac arrhythmia (very rare)

Precautions & Warnings

Before using Normotus Antitussive, consider the following precautions.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown; consult a healthcare professional.
  • Age: not recommended for children under 4 years without medical advice.
  • MAO inhibitor therapy: avoid concurrent use due to risk of serotonin syndrome.
  • Alcohol: limit intake as it may increase drowsiness.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Dextromethorphan may interact with several medicines; monitor accordingly.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome.
  • Selective serotonin reuptake inhibitors (SSRIs): increased serotonin syndrome risk.
  • Monoamine oxidase inhibitor therapy: contraindicated.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Other CNS depressants (e.g., antihistamines, benzodiazepines): may increase drowsiness.
  • Ritonavir: may raise dextromethorphan plasma levels.

Frequently Asked Questions

Normotus Antitussive is an over‑the‑counter medication indicated for the temporary relief of cough caused by minor throat or bronchial irritation. It is intended for adults and children who experience a dry, non‑productive cough and is not meant for treating underlying infections or chronic respiratory conditions.

Dextromethorphan suppresses coughing by acting as a sigma‑1 receptor agonist and an NMDA receptor antagonist. These actions reduce neuronal excitability in the medullary cough centre, decreasing the cough reflex without affecting normal breathing patterns.

The appropriate dose is determined by the prescriber or according to the product label. For most OTC formulations, adults may take 10‑20 mg every 4‑6 hours, not exceeding the maximum daily amount indicated on the packaging. Children’s dosing follows age‑specific recommendations provided by a healthcare professional.

Safety data for dextromethorphan in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only after consulting a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with opioid‑based suppressants such as codeine, dextromethorphan offers a non‑opioid option with a lower risk of dependence and respiratory depression. However, it may interact with serotonergic agents, whereas codeine carries a higher potential for sedation and gastrointestinal side effects.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Normotus Antitussive is taken orally. Swallow the tablet whole with a glass of water. It can be taken with or without food, although taking it with food may reduce mild gastrointestinal discomfort in some individuals.

Serious adverse reactions include allergic responses such as rash or swelling, serotonin syndrome when combined with serotonergic drugs, severe dizziness or hallucinations, and, rarely, respiratory depression. Prompt medical attention is required if any of these symptoms occur.

Individuals with known hypersensitivity to dextromethorphan, children under four years of age, and patients currently receiving monoamine oxidase inhibitors should avoid this medication. Consultation with a healthcare professional is also advised for anyone with significant liver impairment or a history of serotonin‑related disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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