Norphex (Levomepromazine Maleate)

Levomepromazine works by blocking dopamine D2 receptors, which reduces dopaminergic activity associated with psychosis. It also antagonises histamine H1, muscarinic and alpha‑adrenergic receptors, giving it antiemetic, sedative and anticholinergic properties that contribute to its therapeutic effects.

The appropriate dose of Norphex is determined individually by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage regimens are not standardized in public information and should follow the prescriber’s specific instructions.

Safety data for levomepromazine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Clinicians must weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Norphex, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Norphex (levomepromazine) and haloperidol belong to the phenothiazine class, but levomepromazine has broader receptor activity, including stronger antihistamine and anticholinergic effects, which can lead to more pronounced sedation and antiemetic properties. Haloperidol is more selective for dopamine D2 receptors and may cause fewer anticholinergic side effects but can have a higher risk of extrapyramidal symptoms.

Norphex tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Norphex is supplied as oral tablets that are taken by mouth with a glass of water. The tablets should be swallowed whole unless the prescriber advises otherwise. Administration is typically performed under medical supervision, especially during initiation and dose adjustments.

The most serious adverse events associated with levomepromazine include neuroleptic malignant syndrome, severe hypotension, cardiac arrhythmias such as QT‑interval prolongation, and agranulocytosis. Patients should be monitored closely for fever, muscle rigidity, sudden drops in blood pressure, irregular heartbeats, or signs of infection.

Norphex is contraindicated in individuals with known hypersensitivity to levomepromazine or any phenothiazine, in patients with severe cardiovascular disease prone to arrhythmias, and in those with a history of neuroleptic malignant syndrome. Caution is also advised for patients with uncontrolled glaucoma, severe hepatic impairment, or those taking interacting medications listed under major interactions.