Product image of Norprexanil (Amlodipine Besilate, Perindopril Arginine) supplied by GNH India

Norprexanil

Active Ingredient:
Amlodipine Besilate, Perindopril Arginine
Origin:
EU

Norprexanil (Amlodipine Besilate, Perindopril Arginine)

Amlodipine besilate and perindopril arginine, the active ingredients in Norprexanil, are a calcium channel blocker and an ACE inhibitor presented as oral tablets for systemic use. They are prescribed to lower elevated blood pressure in adult patients with hypertension.

GNH India supplies Norprexanil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides batch‑tested products for global distribution, ensuring consistent potency and safety.

Manufacturer / TM Owner

Servier Pharma D.O.O -Croatia

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Indications & Clinical Uses

Norprexanil combines a calcium‑channel blocker and an ACE inhibitor to treat hypertension and related cardiovascular conditions.

  • Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension.
  • High blood pressure: improves blood pressure control when monotherapy is insufficient.
  • Cardiovascular risk reduction: contributes to lowering the risk of stroke and myocardial infarction in hypertensive patients.

How It Works

  • Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Perindopril arginine inhibits angiotensin‑converting enzyme, preventing formation of angiotensin II and decreasing aldosterone release. The combined action results in synergistic reduction of arterial pressure.

Side Effects

Norprexanil may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: sensation of warmth and redness.
  • Dizziness: especially after standing.
  • Cough: dry, non‑productive.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, potentially airway‑obstructing.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Liver dysfunction: elevated transaminases or hepatitis.
  • Myocardial infarction: rare occurrence of heart attack.
  • Renal impairment: worsening kidney function.
  • Neutropenia: low white‑blood‑cell count.

Precautions & Warnings

Before initiating Norprexanil, several precautionary measures should be considered.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Renal function assessment: evaluate serum creatinine and eGFR.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Known hypersensitivity: avoid if patient has reacted to amlodipine, perindopril, or any component.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Norprexanil can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Concomitant ACE inhibitors or ARBs: risk of additive hypotension and renal dysfunction.
  • Aliskiren in diabetic patients: may cause severe hypotension and hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase amlodipine plasma levels.
  • Potassium‑sparing diuretics: elevate risk of hyperkalaemia.
  • NSAIDs (high dose): may blunt antihypertensive effect.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may enhance blood‑pressure lowering.
  • Beta‑blockers: additive effect on heart rate and blood pressure.
  • Lithium: increased lithium levels, monitor serum concentration.
  • Rifampin: may reduce amlodipine concentrations.
  • Grapefruit juice: can raise amlodipine exposure.

Frequently Asked Questions

Norprexanil is a prescription antihypertensive that combines amlodipine besilate and perindopril arginine. It is indicated for the treatment of hypertension in adult patients, helping to lower elevated blood pressure.

Amlodipine besilate is a dihydropyridine calcium‑channel blocker. It inhibits L‑type calcium channels in vascular smooth muscle, leading to vasodilation and a reduction in peripheral vascular resistance, which contributes to lower blood pressure.

Perindopril arginine is an angiotensin‑converting enzyme (ACE) inhibitor. By blocking ACE, it prevents the conversion of angiotensin I to the potent vasoconstrictor angiotensin II and reduces aldosterone secretion, resulting in vasodilation and decreased blood pressure.

The dosage of Norprexanil is individualized. A qualified prescriber determines the appropriate strength and regimen based on the patient’s clinical condition, response, and tolerability.

Safety of amlodipine and perindopril during pregnancy or lactation has not been established. Use is generally avoided unless the potential benefit justifies the risk, and the decision should be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Combining a calcium‑channel blocker with an ACE inhibitor provides additive blood‑pressure control, often achieving target pressures with lower individual doses compared with using either agent alone, and may reduce the need for dose escalation.

Store tablets at room temperature, below 25 °C, in the original packaging, protected from moisture and direct sunlight to maintain stability and potency.

Norprexanil tablets are taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional.

Patients with known hypersensitivity to amlodipine, perindopril, or any excipients, as well as those with severe renal impairment, significant hepatic disease, or a history of angioedema related to ACE inhibitors, should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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