Product image of Norprolac (Quinagolide) supplied by GNH India

Norprolac

Active Ingredient:
Quinagolide
Origin:
EU

Norprolac (Quinagolide)

Quinagolide, the active ingredient in Norprolac, is a dopamine agonist presented as an oral tablet for oral use. It reduces excess prolactin secretion and is typically prescribed by endocrinologists for treatment.
GNH India supplies Norprolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Lægemidler A/S

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Indications & Clinical Uses

Quinagolide acts on the dopaminergic pathway to lower prolactin levels and is indicated for the following conditions:

  • Hyperprolactinemia: normalizes serum prolactin concentrations, alleviating associated symptoms.
  • Prolactinoma: reduces tumor size and prolactin output in patients with pituitary prolactin‑secreting adenomas.
  • Galactorrhea: suppresses inappropriate milk production unrelated to pregnancy or lactation.

How It Works

  • Quinagolide is a selective dopamine D2 receptor agonist. By binding to D2 receptors on lactotroph cells in the anterior pituitary, it inhibits adenylate cyclase activity, decreasing cyclic AMP production and subsequently suppressing prolactin synthesis and release. The drug’s high affinity for the D2 subtype ensures prolonged receptor occupancy, and its oral bioavailability allows systemic exposure sufficient to achieve therapeutic plasma concentrations.

Side Effects

Quinagolide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Valvular heart disease
  • Pulmonary hypertension
  • Severe depression
  • Cardiac arrhythmia

Precautions & Warnings

When prescribing Quinagolide, several safety considerations should be observed.

  • Assess baseline prolactin levels: confirm hyperprolactinemia before initiating therapy.
  • Monitor cardiac function: periodic echocardiography is advised due to potential valvular effects.
  • Evaluate psychiatric status: watch for emergence of depression or psychotic symptoms.
  • Avoid use in patients with uncontrolled hypertension: quinagolide may exacerbate blood pressure.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Quinagolide can interact with other medicines; awareness of the interaction level helps guide clinical decisions.

Major Interactions (Avoid)

  • Concomitant use with ergot‑derived dopamine agonists: additive risk of cardiac valvulopathy.
  • Combination with potent CYP3A4 inhibitors (e.g., ketoconazole): may increase quinagolide plasma levels.
  • Co‑administration with serotonergic agents (e.g., SSRIs): heightened risk of serotonin syndrome.
  • Use with antihypertensive agents: may cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Concurrent use with other dopamine agonists (e.g., cabergoline): may amplify dopaminergic effects.
  • Co‑administration with antipsychotics that block D2 receptors: may reduce therapeutic efficacy.

Frequently Asked Questions

Norprolac contains quinagolide and is prescribed to lower elevated prolactin levels. It is indicated for hyperprolactinemia, prolactin‑secreting pituitary tumors (prolactinoma), and inappropriate milk production (galactorrhea) that is not related to pregnancy or nursing.

Quinagolide selectively stimulates dopamine D2 receptors on pituitary lactotroph cells. This activation suppresses adenylate cyclase activity, reduces cyclic AMP formation, and consequently inhibits the synthesis and release of prolactin, restoring normal hormonal balance.

The dose of Norprolac is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Healthcare professionals determine the appropriate starting dose and any subsequent adjustments; patients should follow the prescriber’s instructions precisely.

Safety data for quinagolide during pregnancy and lactation are limited. Because the drug can affect prolactin, which is important for lactation, it is generally avoided unless the potential benefit outweighs the risk. Physicians should evaluate each case carefully.

To request Norprolac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative to quinagolide is cabergoline, another dopamine agonist. Cabergoline has a longer half‑life and is often dosed less frequently, while quinagolide may be preferred when a shorter‑acting agent is desired. Both agents lower prolactin, but their side‑effect profiles and dosing schedules differ.

Norprolac tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct light, and ensure the packaging remains tightly closed until use.

Norprolac is taken orally, usually with a glass of water. It is typically administered once daily, but the exact timing and whether it should be taken with food are determined by the prescribing physician.

Serious adverse events include valvular heart disease, pulmonary hypertension, severe depression, and cardiac arrhythmias. Patients should report any new chest discomfort, shortness of breath, mood changes, or irregular heartbeats to their healthcare provider promptly.

Norprolac is contraindicated in individuals with known hypersensitivity to quinagolide, uncontrolled hypertension, or pre‑existing severe cardiac valve disease. Caution is also advised for patients with a history of psychiatric disorders or those taking medications that strongly inhibit CYP3A4.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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