Product image of Norprolac (Quinagolide) supplied by GNH India

Norprolac

Active Ingredient:
Quinagolide
Origin:
EU

Norprolac (Quinagolide)

Quinagolide, the active ingredient in Norprolac, is a dopamine agonist presented as an oral tablet for oral use. It is employed to treat hyperprolactinemia, prolactinoma and related infertility in adult patients.
GNH India supplies Norprolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring B.V.

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Indications & Clinical Uses

Quinagolide acts on the dopaminergic pathway to lower excess prolactin production and is indicated for the following conditions:

  • Hyperprolactinemia: reduces elevated serum prolactin levels and alleviates associated symptoms.
  • Prolactinoma: helps shrink pituitary adenomas and normalizes prolactin secretion.
  • Infertility related to elevated prolactin: restores ovulatory cycles and improves fertility potential.

How It Works

  • Quinagolide selectively stimulates dopamine D2 receptors in the anterior pituitary, inhibiting adenylate cyclase activity and suppressing prolactin release. By reducing circulating prolactin, it corrects hormonal imbalances that underlie hyperprolactinemia and its clinical sequelae.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient tension‑type headaches.
  • Dizziness: occasional light‑headedness, especially on standing.
  • Fatigue: general tiredness or reduced energy.

Serious or Rare Side Effects

  • Valvular heart disease: potential fibrotic changes in cardiac valves.
  • Impulse control disorders: compulsive behaviors such as gambling or shopping.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Allergic reactions: rash, urticaria, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor prolactin levels: assess therapeutic response and adjust dose as needed.
  • Assess cardiac function: baseline echocardiography is advised due to valvular risk.
  • Evaluate psychiatric history: watch for impulse control or mood disturbances.
  • Avoid use in uncontrolled hypertension: risk of additive blood‑pressure lowering.
  • Use caution in hepatic impairment: metabolism may be reduced.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Quinagolide may interact with other medicines, requiring attention to the following categories.

Major Interactions (Avoid)

  • Ergot derivatives: combined use can cause severe vasospasm.
  • Potent CYP3A4 inhibitors: may increase quinagolide plasma concentrations.
  • Other dopamine agonists: risk of excessive dopaminergic stimulation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect, monitor blood pressure.
  • SSRIs: potential for serotonin syndrome when combined.
  • Antipsychotics: dopamine antagonism may reduce quinagolide efficacy.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.

Frequently Asked Questions

Norprolac contains quinagolide, a dopamine agonist prescribed to lower high prolactin levels. It is used in the management of hyperprolactinemia, prolactin‑secreting pituitary tumors (prolactinomas), and infertility that results from elevated prolactin.

Quinagolide selectively activates dopamine D2 receptors in the anterior pituitary gland. This activation inhibits adenylate cyclase, reducing the secretion of prolactin and thereby correcting the hormonal imbalance that causes the associated clinical conditions.

The dosage of Norprolac is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Only a qualified healthcare professional should determine the appropriate dose and titration schedule.

Safety data for quinagolide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Norprolac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Norprolac (quinagolide) is a selective dopamine D2‑receptor agonist, similar in class to cabergoline and bromocriptine. Compared with bromocriptine, quinagolide often requires once‑daily dosing and may have a different side‑effect profile, while cabergoline is typically given twice weekly and is associated with a lower incidence of nausea.

Store Norprolac tablets at temperatures below 25 °C, in the original packaging, and protect them from moisture and direct sunlight. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Norprolac is taken orally, usually with water. The tablet should be swallowed whole and not chewed or crushed. It is generally taken once daily, but the exact timing and any food considerations are determined by the prescribing clinician.

Serious risks include valvular heart disease, impulse‑control disorders such as compulsive gambling, severe hypotension, and rare allergic reactions. Patients should be monitored regularly for cardiac symptoms and behavioral changes, and any concerning signs should prompt immediate medical evaluation.

Norprolac is contraindicated in patients with known hypersensitivity to quinagolide, uncontrolled hypertension, severe cardiac valve disease, or those taking ergot‑derived medications. Caution is also advised for individuals with hepatic impairment or a history of psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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