Product image of Norprolac (Quinagolide) supplied by GNH India

Norprolac

Active Ingredient:
Quinagolide
Origin:
EU

Norprolac (Quinagolide)

Quinagolide, the active ingredient in Norprolac, is a dopamine agonist presented as an oral tablet for oral use. It treats hyperprolactinemia and prolactin‑secreting pituitary adenomas in adult patients.

GNH India supplies Norprolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Léciva A.S.

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Indications & Clinical Uses

Quinagolide acts on the dopaminergic pathway to lower excess prolactin levels, making it useful in several endocrine conditions.

  • Hyperprolactinemia: reduces serum prolactin and normalises menstrual cycles and sexual function.
  • Prolactin‑secreting pituitary adenomas: shrinks tumor size and alleviates associated symptoms.
  • Galactorrhea due to hyperprolactinemia: stops inappropriate breast milk production.

How It Works

  • Quinagolide selectively stimulates dopamine D2 receptors in the anterior pituitary, inhibiting adenylate cyclase activity and suppressing prolactin secretion. By restoring dopaminergic tone, it lowers circulating prolactin concentrations, thereby correcting the hormonal imbalance that underlies hyperprolactinemia and related pituitary disorders.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient tension‑type headaches.
  • Dizziness: occasional light‑headedness, especially on standing.
  • Fatigue: generalised tiredness during early therapy.

Serious or Rare Side Effects

  • Valvular heart disease: rare but may present with murmurs.
  • Impulse control disorders: compulsive behaviours such as gambling.
  • Severe hypotension: marked blood pressure drop requiring medical attention.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Pregnancy: avoid unless the potential benefit justifies the risk to the fetus.
  • Breastfeeding: not recommended as the drug may be excreted in milk.
  • Renal impairment: assess kidney function; dose adjustment may be required.
  • Cardiovascular disease: monitor blood pressure and cardiac status.
  • Drug interactions: review concomitant medications for potential conflicts.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Quinagolide may interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): antagonise dopamine receptors and diminish efficacy.
  • Ergot alkaloids: additive vasospasm risk leading to peripheral ischemia.
  • MAO inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may cause additive hypotensive effects.
  • SSRIs: possible increase in serotonin syndrome risk.
  • Hormonal contraceptives: may alter prolactin dynamics and affect efficacy.

Frequently Asked Questions

Norprolac contains quinagolide, a dopamine agonist prescribed to lower elevated prolactin levels. It is indicated for treating hyperprolactinemia and prolactin‑secreting pituitary adenomas, helping to restore normal hormonal balance and alleviate related symptoms such as menstrual disturbances and galactorrhea.

Quinagolide selectively activates dopamine D2 receptors in the anterior pituitary gland. This activation suppresses adenylate cyclase activity, leading to reduced secretion of prolactin. By decreasing circulating prolactin, the drug corrects the hormonal excess that causes the clinical manifestations of hyperprolactinemia.

The appropriate dose of Norprolac is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. Dosage adjustments are made according to therapeutic goals and any relevant patient factors, such as renal function or concomitant medications.

Quinagolide is generally not recommended during pregnancy unless the potential benefit outweighs the risk to the fetus. It is also contraindicated while breastfeeding because the drug can be excreted in breast milk and may affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Norprolac (quinagolide) is a selective dopamine D2‑receptor agonist, similar to cabergoline and bromocriptine. Compared with bromocriptine, quinagolide often has a shorter half‑life and may be associated with fewer gastrointestinal side effects, while cabergoline typically requires less frequent dosing but carries a higher risk of valvular heart disease.

Norprolac tablets should be stored at temperatures below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Norprolac is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Administration timing (e.g., with meals or on an empty stomach) is guided by the prescribing physician based on individual tolerability.

Serious adverse events, though rare, include valvular heart disease, impulse control disorders such as compulsive gambling, and severe hypotension. Patients should be monitored for cardiac symptoms, changes in behaviour, and any sudden drops in blood pressure, and report these promptly to their healthcare provider.

Norprolac is contraindicated in individuals with known hypersensitivity to quinagole or any excipients, patients with uncontrolled hypertension, and those taking potent dopamine antagonists. Caution is also advised for patients with significant cardiac disease, renal impairment, or a history of impulse control disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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