Product image of Norvasc (Amlodipine) supplied by GNH India

Norvasc

Active Ingredient:
Amlodipine
Origin:
EU

Norvasc (Amlodipine)

Amlodipine, the active ingredient in Norvasc, is a calcium channel blocker presented as a tablet for oral use. It treats hypertension and chronic stable angina in adult patients, helping to lower blood pressure and improve chest‑pain symptoms.

GNH India supplies Norvasc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Aps

1
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Indications & Clinical Uses

Norvasc is a calcium channel blocker used in cardiovascular disease management.

  • Hypertension: lowers systemic blood pressure and reduces the risk of cardiovascular complications.
  • Chronic stable angina: improves exercise tolerance and decreases the frequency of angina episodes.

How It Works

  • Amlodipine selectively inhibits the influx of calcium ions through L‑type calcium channels in vascular smooth muscle and cardiac myocytes. This inhibition causes arterial vasodilation, reduces peripheral vascular resistance, and modestly decreases myocardial oxygen demand, resulting in lowered blood pressure and relief of angina symptoms.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Flushing: warm sensation and reddening of the skin.
  • Dizziness or light‑headedness, especially after standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Allergic reactions: rash, pruritus, or angioedema that may necessitate discontinuation.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor blood pressure: ensure adequate control and avoid excessive lowering.
  • Assess cardiac function: use caution in patients with heart failure or recent myocardial infarction.
  • Use caution in hepatic impairment: dose adjustments may be required.
  • Avoid abrupt discontinuation: tapering can prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Amlodipine may interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase amlodipine plasma levels.
  • High‑dose simvastatin (>20 mg): risk of myopathy and rhabdomyolysis.
  • Grapefruit juice: can elevate drug concentrations.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive effects on heart rate and blood pressure.

  • Diuretics: may enhance antihypertensive response, requiring dose adjustment.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce amlodipine effectiveness.

Frequently Asked Questions

Norvasc (amlodipine) is prescribed primarily for managing high blood pressure (hypertension) and for relieving symptoms of chronic stable angina, a type of chest pain caused by reduced blood flow to the heart.

Amlodipine blocks L‑type calcium channels in the smooth muscle of arteries, preventing calcium entry that would cause contraction. This results in vasodilation, reduced peripheral resistance, and consequently lower arterial pressure.

The specific dose of Norvasc is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for amlodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Norvasc, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with ACE inhibitors or beta‑blockers, amlodipine offers once‑daily dosing and a lower incidence of cough. It is particularly useful when vasodilation is desired, but may cause peripheral edema more frequently than some alternatives.

Norvasc tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Norvasc is taken orally, usually once a day, with or without food. Swallow the tablet whole with a glass of water; do not crush or chew it unless directed by a healthcare professional.

Serious adverse events, though rare, include severe hypotension, myocardial infarction, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, or swelling of the face and throat.

Norvasc is contraindicated in individuals with known hypersensitivity to amlodipine or any other calcium channel blocker. Caution is also advised for patients with severe aortic stenosis, unstable heart failure, or significant liver disease, as determined by their physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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