Product image of Norvasc (Amlodipine) supplied by GNH India

Norvasc

Active Ingredient:
Amlodipine
Origin:
EU

Norvasc (Amlodipine)

Amlodipine, the active ingredient in Norvasc, is a calcium channel blocker presented as a tablet for oral use. It treats hypertension and angina in adults. It works by relaxing blood vessels, which helps lower blood pressure and improves blood flow to the heart. It is commonly prescribed for patients with high blood pressure or stable chest pain.

GNH India supplies Norvasc as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and healthcare providers across multiple regions worldwide globally.

Manufacturer / TM Owner

Viatris Aps

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Indications & Clinical Uses

Amlodipine, a calcium channel blocker, is used to manage conditions related to high blood pressure and coronary artery disease.

  • Hypertension: reduces systolic and diastolic blood pressure, improving cardiovascular risk profile.
  • Chronic stable angina: alleviates chest pain by improving myocardial oxygen supply.
  • Coronary artery disease: helps prevent ischemic events by lowering vascular resistance.

How It Works

  • Amlodipine selectively inhibits the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac myocytes. By reducing intracellular calcium, it causes dose‑dependent relaxation of arterial smooth muscle, leading to vasodilation and decreased peripheral vascular resistance. The resulting fall in blood pressure reduces cardiac afterload, while coronary artery dilation improves myocardial oxygen delivery.

Side Effects

Amlodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate headache, often early in treatment.
  • Peripheral edema: swelling of ankles or feet due to fluid retention.
  • Flushing: transient warmth and redness of the skin.
  • Dizziness: light‑headedness, especially on standing.

Serious or Rare Side Effects

  • Hypotension: significant blood pressure drop that may cause fainting.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe allergic reaction: rash, itching, swelling, or breathing difficulty.

Precautions & Warnings

When prescribing amlodipine, clinicians should consider several precautionary measures to ensure safe use.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Heart failure: use cautiously in patients with severe heart failure due to potential fluid retention.
  • Liver impairment: dose adjustment may be needed in moderate to severe hepatic dysfunction.
  • Concomitant CYP3A4 inhibitors: monitor for increased plasma levels when used with strong inhibitors.
  • Pregnancy and lactation: avoid unless benefits outweigh risks, as safety data are limited.
  • Store at ambient temperature: keep below 25°C, in original container, protect from moisture and light.

Avoid Interactions

Amlodipine can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase amlodipine concentrations, risking hypotension.
  • Simvastatin high doses: combined use can raise simvastatin levels, increasing risk of myopathy.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, phenytoin): may reduce amlodipine effectiveness.
  • Beta‑blockers: additive effect on blood pressure and heart rate.
  • Diuretics: may enhance antihypertensive effect, requiring monitoring for volume depletion.

Frequently Asked Questions

Norvasc, which contains the active ingredient amlodipine, is prescribed for the management of hypertension, chronic stable angina, and coronary artery disease. By lowering blood pressure and improving coronary blood flow, it helps reduce the risk of cardiovascular events in these patient groups.

Amlodipine blocks L-type calcium channels in vascular smooth muscle and cardiac cells, decreasing calcium entry. This causes relaxation of arterial smooth muscle, leading to vasodilation, reduced peripheral resistance, and ultimately a fall in systemic blood pressure.

The appropriate dose of amlodipine is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for amlodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Amlodipine belongs to the calcium channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a lower incidence of cough and does not affect heart rate as markedly, but it may be more likely to cause peripheral edema.

Norvasc tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and store out of reach of children.

Norvasc is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise instructed by a healthcare professional.

Serious adverse events, though rare, include severe hypotension, significant liver enzyme elevation (hepatotoxicity), and severe allergic reactions such as rash, swelling or difficulty breathing. Patients should seek immediate medical attention if these symptoms occur.

Amlodipine is contraindicated in patients with known hypersensitivity to amlodipine or any component of the formulation. Caution is advised in individuals with severe aortic stenosis, unstable heart failure, or significant liver impairment, and it should be avoided in pregnancy unless clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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