Product image of Norvasc (Amlodipine) supplied by GNH India

Norvasc

Active Ingredient:
Amlodipine
Origin:
EU

Norvasc (Amlodipine)

Amlodipine, the active ingredient in Norvasc, is a calcium channel blocker presented as an oral tablet for oral use. It reduces peripheral vascular resistance, helping to control high blood pressure and to prevent angina episodes in patients with chronic stable angina or coronary artery disease.

GNH India supplies Norvasc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent product quality, regulatory adherence, and reliable logistics for global healthcare providers through established distribution networks and dedicated support teams.

Manufacturer / TM Owner

Upjohn Eesv

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Indications & Clinical Uses

Norvasc (amlodipine) is used in the management of cardiovascular conditions related to elevated blood pressure and myocardial oxygen demand.

  • Hypertension: lowers systolic and diastolic blood pressure, improving overall blood pressure control.
  • Chronic stable angina: reduces the frequency of angina attacks by enhancing coronary blood flow.
  • Coronary artery disease: helps prevent progression of ischemic heart disease by decreasing cardiac workload.

How It Works

  • Amlodipine selectively inhibits calcium influx through L-type calcium channels in vascular smooth muscle and cardiac muscle. This inhibition leads to vasodilation of peripheral arteries, reduced systemic vascular resistance, and decreased myocardial oxygen demand, thereby lowering blood pressure and alleviating angina symptoms.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often occurring after the first dose.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or feet due to fluid retention.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.
  • Fatigue: general feeling of tiredness or lack of energy.
  • Palpitations: awareness of heartbeats that may feel irregular.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure that can cause fainting.
  • Myocardial infarction: rare occurrence of heart attack.
  • Arrhythmia: abnormal heart rhythms requiring medical attention.
  • Elevated liver enzymes: indication of possible hepatic stress.
  • Allergic reactions: rash, itching, or swelling of the face and throat.
  • Stevens‑Johnson syndrome: rare but serious skin disorder.

Precautions & Warnings

Before starting therapy, patients should be evaluated for cardiovascular status and liver function.

  • Monitor blood pressure: check regularly after initiation or dose adjustments.
  • Assess cardiac function: use caution in patients with heart failure or recent myocardial infarction.
  • Adjust in hepatic impairment: consider lower doses in moderate liver disease.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Amlodipine may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): increase amlodipine plasma levels.
  • Concurrent potent vasodilators (e.g., nitroglycerin): risk of severe hypotension.
  • High‑dose simvastatin (>20 mg): elevated risk of statin‑related toxicity.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin): may reduce amlodipine effectiveness.

  • Beta‑blockers: additive effect on heart rate and blood pressure.
  • Diuretics: enhanced antihypertensive response, monitor electrolytes.

Frequently Asked Questions

Norvasc (amlodipine) is prescribed to manage high blood pressure (hypertension) and to relieve chest pain caused by chronic stable angina. It is also used in patients with coronary artery disease to reduce cardiac workload and improve blood flow to the heart.

Amlodipine blocks L‑type calcium channels in vascular smooth muscle and cardiac muscle. This action prevents calcium from entering cells, causing the blood vessels to relax and widen, which lowers peripheral resistance and reduces blood pressure while also decreasing the heart's oxygen demand.

The appropriate dose of Norvasc is determined individually by a qualified healthcare professional based on the patient’s medical condition, response to therapy, and any other medications being taken. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Amlodipine is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no well‑controlled studies in pregnant women. It should only be used if the potential benefit justifies the potential risk. Breastfeeding mothers should consult their physician, as the drug does pass into breast milk.

To place an order, submit an enquiry on the Norvasc product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Norvasc belongs to the calcium channel blocker class, which primarily causes vasodilation. Compared with ACE inhibitors or beta‑blockers, amlodipine has a longer half‑life, allowing once‑daily dosing, and is less likely to cause cough or bronchospasm. Choice of therapy depends on patient comorbidities and physician preference.

Store Norvasc at room temperature, below 25 °C (77 °F). Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Norvasc is taken orally, usually once daily with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and should not crush or chew the tablet.

Serious adverse events, although rare, include severe hypotension, myocardial infarction, life‑threatening arrhythmias, and severe allergic reactions such as Stevens‑Johnson syndrome. Patients experiencing fainting, chest pain, rapid heartbeat, or signs of an allergic reaction should seek immediate medical attention.

Norvasc should be used with caution or avoided in patients with known hypersensitivity to amlodipine or other calcium channel blockers, severe aortic stenosis, uncontrolled heart failure, or significant liver disease. Pregnant or breastfeeding women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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