Product image of Norvasc (Amlodipine Besilate) supplied by GNH India

Norvasc

Active Ingredient:
Amlodipine Besilate
Origin:
EU

Norvasc (Amlodipine Besilate)

Amlodipine besilate, the active ingredient in Norvasc, is a calcium channel blocker presented as an oral tablet for oral use. It is used to treat high blood pressure and chest pain in adults.

GNH India supplies Norvasc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Pharma S.R.L.

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Indications & Clinical Uses

Norvasc, a calcium channel blocker, is employed in cardiovascular conditions to improve blood flow and reduce cardiac workload.

  • Hypertension: lowers systemic blood pressure and reduces the risk of cardiovascular complications.
  • Chronic stable angina: decreases the frequency of angina attacks by improving coronary blood supply.
  • Coronary artery disease: helps prevent ischemic episodes by dilating coronary arteries.

How It Works

  • Amlodipine besilate blocks L-type calcium channels in vascular smooth muscle and cardiac myocytes, inhibiting calcium influx. This results in arterial vasodilation, reduced peripheral vascular resistance, and modest negative inotropic effects, thereby lowering blood pressure and relieving myocardial oxygen demand.

Side Effects

Adverse reactions may occur with amlodipine therapy and are categorized by frequency.

Common Side Effects

  • Peripheral edema: swelling of the ankles or feet.
  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Dizziness: especially upon standing.
  • Fatigue: general tiredness.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure.
  • Myocardial infarction: rare but possible cardiac event.
  • Elevated liver enzymes: indicating hepatic stress.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Blood dyscrasias: neutropenia or thrombocytopenia.
  • Heart block: conduction abnormalities.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific factors and monitor for potential complications.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Cardiac assessment: review heart rate and rhythm, especially in patients with conduction disorders.
  • Concomitant drugs: assess for interactions that may amplify blood pressure effects.
  • Hepatic impairment: use with caution; dose adjustments may be required.
  • Discontinuation: avoid abrupt cessation to prevent rebound hypertension.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Amlodipine may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can markedly increase amlodipine levels.
  • Simvastatin >20 mg: risk of myopathy and rhabdomyolysis.
  • Grapefruit juice: may raise plasma concentrations.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive effects on heart rate and blood pressure.

  • Diuretics: may enhance hypotensive response.

Frequently Asked Questions

Norvasc (amlodipine besilate) is prescribed for managing hypertension, relieving chronic stable angina, and supporting treatment of coronary artery disease by improving blood flow to the heart.

Amlodipine blocks L‑type calcium channels in arterial smooth muscle, preventing calcium entry, which relaxes the vessels, lowers peripheral resistance, and consequently reduces blood pressure.

The appropriate dose of Norvasc is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications.

Safety of amlodipine in pregnancy or while nursing has not been definitively established; it should only be used if the potential benefit justifies any potential risk to the fetus or infant.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with beta‑blockers or ACE inhibitors, amlodipine offers once‑daily dosing and a lower incidence of cough, but it may cause peripheral edema more frequently. Choice depends on individual patient profile and comorbidities.

Store Norvasc at ambient temperature, preferably below 25 °C, in the original packaging, protected from moisture and direct sunlight to maintain product stability.

Norvasc is taken orally, usually once daily with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe hypotension, myocardial infarction, significant liver enzyme elevation, allergic reactions such as anaphylaxis, and rare cardiac conduction disturbances like heart block.

Patients with known hypersensitivity to amlodipine or any component of the formulation, those with severe aortic stenosis, or individuals with unstable heart failure should avoid using Norvasc unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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