Product image of Nosatel (Dexketoprofen) supplied by GNH India

Nosatel

Active Ingredient:
Dexketoprofen
Origin:
EU

Nosatel (Dexketoprofen)

Dexketoprofen, the active ingredient in Nosatel, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It provides rapid analgesic and anti‑inflammatory effects, making it suitable for managing acute, postoperative and musculoskeletal pain in adult patients.

GNH India supplies Nosatel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Dexketoprofen is an NSAID used to manage pain and inflammation in several acute conditions.
  • Acute pain: provides rapid relief of moderate to severe pain.
  • Postoperative pain: reduces pain after surgical procedures.
  • Musculoskeletal pain: alleviates pain associated with injuries or strain.

How It Works

  • Dexketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at the site of injury, it diminishes peripheral sensitisation and produces analgesic and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with dexketoprofen administration.

Common Side Effects

  • Nausea
  • Dyspepsia
  • Headache
  • Injection site pain

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding
  • Renal impairment
  • Severe allergic reactions (anaphylaxis)
  • Hepatic dysfunction

Precautions & Warnings

  • When using Nosatel, consider the following safety measures.
  • Assess renal function: evaluate baseline kidney status before initiation.
  • Assess hepatic function: check liver enzymes in patients with liver disease.
  • Use the lowest effective dose: limit exposure to the minimum required for pain control.
  • Avoid in known NSAID hypersensitivity: contraindicated for patients with prior allergic reactions to NSAIDs.
  • Monitor cardiovascular risk: use cautiously in patients with hypertension or heart disease.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Dexketoprofen may interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: may exacerbate renal impairment.

Frequently Asked Questions

Nosatel is an injectable formulation of dexketoprofen, indicated for the short‑term management of acute pain, postoperative pain, and musculoskeletal pain in adult patients. It is administered by a healthcare professional to provide rapid analgesic and anti‑inflammatory relief in clinical settings.

Dexketoprofen blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the production of prostaglandins. By reducing prostaglandin synthesis, it lowers inflammation, pain signalling, and fever, resulting in fast‑acting analgesic and anti‑inflammatory effects at the site of injury.

The specific dose and frequency of Nosatel are determined by the prescribing clinician based on the severity of pain, the patient’s clinical condition, and the route of administration. Healthcare professionals adjust the regimen to achieve effective pain control while minimising risk.

Safety data for dexketoprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To order Nosatel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

Nosatel (dexketoprofen) is a potent NSAID with a rapid onset of action compared with traditional ketoprofen or ibuprofen. Its enantiomeric form often provides effective pain relief at lower doses, potentially reducing gastrointestinal side‑effects, though it shares the class‑related risks of renal and cardiovascular events.

Nosatel should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures. Do not freeze the solution, and ensure that vials are kept upright to avoid agitation before use.

Nosatel is supplied as a sterile injectable solution for intramuscular (IM) or intravenous (IV) administration. The injection is performed by a qualified healthcare professional using aseptic technique, with the dose and route selected according to the patient’s clinical needs and the prescriber’s instructions.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe allergic reactions such as anaphylaxis, and hepatic dysfunction. Patients should be monitored for signs of these events, especially if they have a history of ulcer disease, kidney problems, or are taking interacting medications.

Nosatel is contraindicated in patients with known hypersensitivity to dexketoprofen or any NSAID, those with active gastrointestinal bleeding or ulcer, severe renal or hepatic impairment, and in individuals who have experienced severe cardiovascular events related to NSAID use. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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