Product image of Nosca Méréprine (Noscapine Hydrochloride Monohydrate) supplied by GNH India

Nosca Méréprine

Active Ingredient:
Noscapine Hydrochloride Monohydrate
Origin:
EU

Nosca Méréprine (Noscapine Hydrochloride Monohydrate)

Noscapine, the active ingredient in Nosca Méréprine, is an antitussive presented as an oral formulation for oral use. It acts as a non‑opioid cough suppressant that modulates the central cough reflex, providing relief of dry, non‑productive coughs in both adult and pediatric patients when indicated.

GNH India supplies Nosca Méréprine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards for export. The product conforms to European Union pharmacopeial specifications and is manufactured under GMP conditions.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

Noscapine is used as a non‑opioid antitussive that suppresses the cough reflex in various respiratory conditions.

  • Non‑productive cough: reduces frequency and intensity of dry cough episodes.
  • Upper respiratory tract infection cough: offers symptomatic relief during viral colds.
  • Post‑viral cough: helps suppress lingering cough after viral illness.

How It Works

  • Noscapine hydrochloride monohydrate exerts its antitussive effect primarily by modulating sigma‑1 receptors in the central nervous system. This interaction attenuates the neuronal pathways that trigger the cough reflex without engaging opioid receptors, resulting in cough suppression while avoiding typical opioid‑related side effects.

Side Effects

Noscapine is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: transient sensation of light‑headedness.
  • Headache: occasional mild headache.
  • Drowsiness: mild sedation, especially at higher doses.
  • Gastrointestinal discomfort: mild abdominal cramping or constipation.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, or swelling of the face and throat.
  • Hepatic enzyme elevation: rare increase in liver function tests.
  • Hematologic abnormalities: very rare cases of neutropenia or thrombocytopenia.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: extremely rare, rapid onset of systemic allergic response.

Precautions & Warnings

When considering Nosca Méréprine, several safety measures should be observed.

  • Pregnancy: safety not established; avoid unless clearly needed.
  • Breastfeeding: unknown excretion; weigh benefits against potential risks.
  • Renal impairment: use with caution; monitor renal function.
  • Hepatic disease: consider dose adjustment; monitor liver enzymes.
  • Known hypersensitivity: discontinue if allergic signs appear.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Noscapine may interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase noscapine plasma concentrations.
  • Co‑administration with other opioid‑containing antitussives (e.g., codeine): risk of additive central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Sedatives or antihistamines: may enhance drowsiness.
  • MAO inhibitors: monitor for heightened central effects.
  • Drugs that prolong QT interval: observe cardiac rhythm.
  • Anticoagulants: potential alteration of bleeding risk.
  • Herbal supplements (e.g., St. John’s Wort): may affect metabolic pathways.

Frequently Asked Questions

Nosca Méréprine contains noscapine, a non‑opioid antitussive indicated for the symptomatic relief of dry, non‑productive coughs. It is commonly prescribed when a cough is persistent, irritating, or interferes with sleep, and when an opioid‑based cough suppressant is not desired.

Noscapine acts by modulating sigma‑1 receptors in the central nervous system, which dampens the neuronal signaling that initiates the cough reflex. This mechanism provides cough suppression without engaging opioid receptors, thereby minimizing typical opioid‑related adverse effects.

The appropriate dose of Nosca Méréprine is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of cough, and overall clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for noscapine in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nosca Méréprine (noscapine) offers cough suppression without opioid activity, reducing the risk of dependence, respiratory depression, and constipation associated with codeine. However, codeine may provide stronger analgesic effects, which noscapine lacks. Choice of therapy depends on patient-specific factors, including opioid tolerance and safety considerations.

Store Nosca Méréprine at ambient temperature, preferably below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain stability. Keep out of reach of children and do not use if the packaging appears damaged.

Nosca Méréprine is taken orally. The tablet or capsule should be swallowed whole with a glass of water, unless the prescriber advises otherwise. It is usually taken with or without food, following the dosing schedule provided by the healthcare professional.

Serious risks, though rare, include severe allergic reactions such as rash, swelling, or anaphylaxis, as well as hepatic enzyme elevations and hematologic abnormalities like neutropenia. Patients should seek immediate medical attention if they experience signs of a serious reaction.

Individuals with a known hypersensitivity to noscapine or any component of the formulation should avoid the product. Caution is also advised for patients with significant liver or kidney impairment, and it is generally contraindicated during pregnancy unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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