Product image of Nosca-Méréprine (Noscapine Hydrochloride Monohydrate) supplied by GNH India

Nosca-Méréprine

Active Ingredient:
Noscapine Hydrochloride Monohydrate
Origin:
EU

Nosca-Méréprine (Noscapine Hydrochloride Monohydrate)

Noscapine hydrochloride monohydrate, the active ingredient in Nosca-Méréprine, is an antitussive presented as an oral dosage form for oral use. It suppresses non‑productive cough in adults and children.\n\nGNH India supplies Nosca-Méréprine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

  • Nosca-Méréprine acts as a central cough suppressant and is used for conditions involving irritating cough reflexes.\n\nNon‑productive cough: reduces cough frequency and provides symptomatic relief.\nAcute cough due to upper respiratory infection: helps suppress cough episodes during the early phase of infection.\nChronic non‑productive cough in adults: aids in cough control when other causes have been excluded.

How It Works

  • Noscapine hydrochloride monohydrate exerts its antitussive effect by modulating central nervous system pathways, likely through antagonism of sigma‑1 receptors and inhibition of cough‑inducing neurotransmission in the medullary cough center, thereby reducing the cough reflex without significant opioid activity.

Side Effects

  • Common Side Effects:\n- Drowsiness: mild sleepiness may occur after oral administration.\n- Nausea: occasional stomach upset reported.\n- Dizziness: transient light‑headedness in some patients.\n- Dry mouth: reduced salivation leading to a dry sensation.\n\nSerious or Rare Side Effects:\n- Allergic reactions: rash, itching, or angioedema requiring medical attention.\n- Severe skin reactions: rare cases of Stevens‑Johnson syndrome.\n- Hepatic enzyme elevation: occasional abnormal liver function tests observed.

Precautions & Warnings

  • Before using Nosca-Méréprine, consider the following precautions.\n\nPregnancy: safety not established; use only if clearly needed.\nBreastfeeding: unknown safety; weigh potential risks and benefits.\nRenal impairment: use with caution and monitor renal function.\nDrug interactions: review all concomitant medications for possible interactions.\nStore at ambient temperature (below 25°C): keep in the original pack, protect from moisture.

Avoid Interactions

  • Nosca-Méréprine may interact with other substances that affect the central nervous system.\n\nMajor Interactions (Avoid):\n- Concurrent use with potent CNS depressants: may enhance sedation and respiratory depression.\n- Combination with MAO inhibitors: not recommended due to unknown interaction risk.\n\nModerate Interactions (Monitor Closely):\n- Antihistamines: may increase antitussive effect and cause excess drowsiness.\n- Opioid cough suppressants: additive cough‑suppressing effect could lead to over‑suppression.\n- Alcohol: may potentiate drowsiness and dizziness.

Frequently Asked Questions

Nosca-Méréprine contains noscapine hydrochloride monohydrate and is used as an over‑the‑counter antitussive to relieve non‑productive or dry coughs associated with upper respiratory infections in both adults and children.

Noscapine hydrochloride acts on the central nervous system, likely by antagonizing sigma‑1 receptors and modulating cough‑related neurotransmission in the brainstem, which reduces the cough reflex without the opioid‑related side effects.

The appropriate dose of Nosca-Méréprine is determined by the prescribing healthcare professional based on the patient’s age, weight, and severity of cough. Patients should follow the prescriber’s instructions and the product label.

Safety data for noscapine hydrochloride in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike opioid‑based cough medicines, noscapine provides antitussive relief without significant risk of dependence or respiratory depression. It is generally considered safer for short‑term use, though efficacy may be comparable for dry cough relief.

Store Nosca-Méréprine at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.

Nosca-Méréprine is taken orally, usually as a tablet or liquid preparation, as directed by the prescriber. It should be swallowed with water and not chewed unless the formulation specifically allows it.

Serious risks, though rare, include allergic reactions such as rash, angioedema, or severe skin conditions like Stevens‑Johnson syndrome, as well as possible liver enzyme elevations. Any signs of hypersensitivity require immediate medical attention.

Individuals with known hypersensitivity to noscapine or any component of the formulation should avoid using Nosca-Méréprine. It is also contraindicated in patients where cough suppression could mask serious underlying conditions without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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