Product image of Noskapin Dak (Noscapine Hydrochloride) supplied by GNH India

Noskapin Dak

Active Ingredient:
Noscapine Hydrochloride
Origin:
EU

Noskapin Dak (Noscapine Hydrochloride)

Noscapine Hydrochloride, the active ingredient in Noskapin Dak, is an antitussive presented as an oral formulation for oral use. It is employed to suppress coughing episodes, particularly dry or non‑productive coughs, in adult patients, working centrally to reduce the cough reflex without narcotic effects.

GNH India supplies Noskapin Dak as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable global distribution. The product is manufactured under EU GMP guidelines to ensure consistency and safety.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Noskapin Dak, containing noscapine hydrochloride, acts on the central cough pathway to provide symptomatic relief of cough.

  • Dry cough: reduces frequency and intensity of non‑productive cough episodes
  • Upper respiratory tract irritation: alleviates cough associated with throat irritation
  • Post‑viral cough: helps control lingering cough after viral infections

How It Works

  • Noscapine hydrochloride exerts its antitussive effect by acting on the medullary cough centre in the brainstem. It modulates sigma‑1 receptors and interferes with the transmission of cough‑inducing signals, thereby decreasing the sensitivity of the cough reflex without affecting respiratory drive or causing sedation. The compound does not possess opioid activity, which distinguishes it from narcotic cough suppressants, and its central action is thought to involve inhibition of neuronal calcium influx that contributes to cough generation.

Side Effects

Noskapin Dak may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset may occur
  • Dizziness: transient light‑headedness reported
  • Drowsiness: occasional sedation
  • Headache: mild headache may be experienced

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing
  • Hepatic dysfunction: elevated liver enzymes or jaundice
  • Severe hypotension: sudden drop in blood pressure

Precautions & Warnings

When prescribing Noskapin Dak, clinicians should consider the following precautions to ensure safe use.

  • Pregnancy: safety has not been established; avoid unless benefits outweigh risks
  • Breastfeeding: unknown excretion in milk; use with caution
  • Renal impairment: dose adjustment may be required in severe kidney dysfunction
  • Concomitant CNS depressants: may enhance sedative effects
  • Hypersensitivity: discontinue if allergic reaction occurs
  • Store at ambient temperature: keep in original packaging, protect from moisture and light

Avoid Interactions

Noskapin Dak can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • CYP3A4 inhibitors: may increase noscapine plasma concentrations
  • CNS depressants: additive sedation or respiratory depression
  • Anticoagulants: potential enhancement of bleeding risk

Moderate Interactions (Monitor Closely)

  • Antihistamines: may potentiate antitussive effect
  • Other antitussives: risk of excessive cough suppression

Frequently Asked Questions

Noskapin Dak is used as a cough suppressant to relieve dry or non‑productive coughs. It targets the central cough centre to reduce the frequency and intensity of coughing episodes, providing symptomatic relief without the narcotic effects associated with some other antitussives.

Noscapine acts on the medullary cough centre in the brainstem, modulating sigma‑1 receptors and inhibiting neuronal calcium influx. This reduces the transmission of cough‑inducing signals, decreasing the sensitivity of the cough reflex while preserving normal respiratory function.

The appropriate dose of Noskapin Dak is determined by a qualified prescriber based on the patient’s condition, age, and overall health. Dosage instructions are individualized and should follow the healthcare professional’s recommendation.

Safety of noscapine hydrochloride in pregnancy and lactation has not been established. It is generally advised to avoid use during pregnancy unless the potential benefit outweighs the risk, and to exercise caution while breastfeeding, discussing options with a healthcare provider.

To order Noskapin Dak, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

The most common alternative antitussive is codeine, an opioid that can cause sedation, constipation, and dependence. Noskapin Dak, containing noscapine, offers cough suppression without opioid‑related side effects, making it a preferable option for patients who need a non‑narcotic treatment.

Store Noskapin Dak at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and potency throughout its shelf life.

Noskapin Dak is taken orally as directed by a healthcare professional. The tablet or oral formulation should be swallowed with water, and it may be taken with or without food depending on the prescriber’s guidance.

Serious risks, though rare, include allergic reactions such as rash, swelling, or breathing difficulties, hepatic dysfunction indicated by abnormal liver enzymes or jaundice, and severe hypotension leading to faintness or shock. Immediate medical attention is required if any of these occur.

Individuals with known hypersensitivity to noscapine or any component of the formulation should avoid Noskapin Dak. It is also contraindicated in patients where cough suppression could mask serious respiratory conditions, and caution is advised for those with severe renal impairment or on interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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