Product image of Noskapin Orifarm Healthcare (Noscapine Hydrochloride) supplied by GNH India

Noskapin Orifarm Healthcare

Active Ingredient:
Noscapine Hydrochloride
Origin:
EU

Noskapin Orifarm Healthcare (Noscapine Hydrochloride)

Noscapine Hydrochloride, the active ingredient in Noskapin Orifarm Healthcare, is an antitussive presented as an oral dosage form for oral use. Originating from the European Union market, this over‑the‑counter product suppresses non‑productive coughs in adults and children by acting centrally on the cough reflex, offering symptomatic relief without significant sedation.

GNH India supplies Noskapin Orifarm Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. All batches meet EU pharmacopeial specifications and are shipped under controlled conditions to ensure product integrity.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Noskapin (noscapine hydrochloride) is an antitussive that acts on the central cough pathway.

  • Non‑productive cough: reduces cough frequency and intensity in patients with dry cough.
  • Cough due to upper respiratory tract infection: provides symptomatic relief during viral colds.
  • Cough associated with bronchitis: helps alleviate persistent dry cough in acute bronchitis.

How It Works

  • Noscapine hydrochloride acts as a centrally acting cough suppressant, likely modulating sigma‑1 receptors in the brainstem to dampen the cough reflex. By influencing neuronal signaling pathways involved in cough generation, it reduces the urge to cough without producing significant sedation or opioid‑like effects.

Side Effects

Noskapin may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Dry mouth

Serious or Rare Side Effects

  • Allergic reactions (rash, urticaria, angioedema)
  • Hepatotoxicity (elevated liver enzymes).

Precautions & Warnings

Before using Noskapin, consider the following precautions.

  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown; weigh potential risks against benefits.
  • Renal impairment: no dosage adjustment required, but monitor severe cases.
  • Hepatic impairment: use with caution and monitor liver function.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Noskapin can interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of additive central nervous system effects.
  • CNS depressants (e.g., opioids, benzodiazepines): may enhance sedation.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase dizziness.
  • CYP450 substrates: noscapine may inhibit certain enzymes; monitor plasma levels.
  • Anticholinergic agents: may exacerbate dry mouth.

Frequently Asked Questions

Noskapin contains noscapine hydrochloride, an antitussive indicated for the symptomatic relief of non‑productive (dry) coughs, including coughs associated with upper respiratory tract infections and acute bronchitis.

Noscapine acts centrally by modulating sigma‑1 receptors in the brainstem, which dampens the neural pathways that trigger the cough reflex, thereby reducing the frequency and intensity of coughing without significant sedation.

The appropriate dose of Noskapin is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product label.

Safety data for noscapine hydrochloride in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Noskapin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with opioid‑based suppressants such as codeine, noscapine offers cough relief without the risk of dependence or significant respiratory depression. Unlike dextromethorphan, it has a distinct central mechanism involving sigma‑1 receptors, which may result in a different side‑effect profile.

Store Noskapin at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Noskapin is administered orally. The tablet or capsule (form not specified) should be swallowed with water, following the dosage instructions provided by the prescriber or printed on the label.

Serious but rare risks include allergic reactions such as rash, urticaria, angioedema, and potential hepatotoxicity manifested by elevated liver enzymes. Patients should seek immediate medical attention if they experience signs of an allergic response or liver dysfunction.

Noskapin should be avoided in individuals with known hypersensitivity to noscapine or any excipients, and in patients who have experienced severe allergic reactions to similar antitussive agents. Caution is advised for those with significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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