Product image of Noskapin Orifarm Healthcare (Noscapine Hydrochloride Monohydrate) supplied by GNH India

Noskapin Orifarm Healthcare

Active Ingredient:
Noscapine Hydrochloride Monohydrate
Origin:
EU

Noskapin Orifarm Healthcare (Noscapine Hydrochloride Monohydrate)

Noscapine Hydrochloride Monohydrate, the active ingredient in Noskapin Orifarm Healthcare, is an antitussive presented as an oral formulation for oral use. It is used to suppress dry and non‑productive coughs in adults and children as directed by a healthcare professional.

GNH India supplies Noskapin Orifarm Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Noscapine is a non‑opioid antitussive that acts on the central cough centre to reduce cough reflex.

  • Dry cough: decreases the frequency and intensity of coughing episodes.
  • Non‑productive cough: suppresses cough without producing sputum.
  • Cough due to upper‑respiratory irritation: provides symptomatic relief of irritation‑induced coughing.

How It Works

  • Noscapine acts as a non‑opioid antitussive by modulating neuronal excitability in the central cough centre, likely through interaction with sigma‑1 receptors and inhibition of calcium‑dependent neurotransmission, thereby reducing the cough reflex without affecting respiratory drive.

Side Effects

Common Side Effects

  • Nausea: mild gastrointestinal upset may occur.
  • Dizziness: transient light‑headedness reported by some users.
  • Drowsiness: occasional sedation, especially at higher doses.
  • Headache: mild headache may be experienced.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, or anaphylaxis in hypersensitive individuals.
  • Severe skin reactions: rare cases of Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes reported rarely.
  • Neutropenia: uncommon reduction in white blood cell count.
  • Respiratory depression: extremely rare, usually with concomitant CNS depressants.

Precautions & Warnings

Before using Noskapin Orifarm Healthcare, consider the following precautions.

  • Pediatric use: follow prescriber guidance for children, as dosing may differ.
  • Hypersensitivity: avoid if known allergy to noscapine or excipients.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Concomitant cough suppressants: do not combine with other antitussives without medical advice.
  • Sedation risk: avoid operating machinery if drowsiness occurs.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Noskapin Orifarm Healthcare may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Central nervous system depressants: may increase sedation and respiratory depression.
  • Other antitussives: combined use can lead to excessive cough suppression.
  • Opioid cough suppressants: additive CNS effects should be avoided.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance drowsiness and dizziness.
  • Antihistamines: may increase sedation when taken together.
  • CYP450 inhibitors: potential alteration of noscapine metabolism, requiring monitoring.

Frequently Asked Questions

Noskapin Orifarm Healthcare contains noscapine, an over‑the‑counter antitussive used to relieve dry and non‑productive coughs. It works by suppressing the cough reflex in the central nervous system, providing symptomatic relief for patients experiencing irritating coughs without producing sputum.

Noscapine modulates neuronal activity in the central cough centre, likely through interaction with sigma‑1 receptors and inhibition of calcium‑dependent excitability. This reduces the transmission of cough signals without affecting normal respiratory function, offering a non‑opioid approach to cough control.

The appropriate dose of Noskapin Orifarm Healthcare is determined by a qualified prescriber based on the patient’s age, weight, and clinical condition. Patients should follow the healthcare professional’s instructions and not exceed the recommended amount.

Safety data for noscapine in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit ratio before prescribing to pregnant or nursing mothers, and use only if clearly needed and approved by the prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noskapin (noscapine) is a non‑opioid antitussive, distinguishing it from opioid‑based cough medicines such as codeine. It offers cough relief with a lower risk of dependence and respiratory depression, though it may cause mild sedation. Its mechanism via sigma‑1 receptors differs from the central µ‑opioid receptor activity of opioid suppressants.

Store Noskapin Orifarm Healthcare below 25 °C in a dry environment. Keep the product in its original packaging to protect it from moisture and light. Do not store in extreme temperatures or humid conditions to maintain potency.

Noskapin Orifarm Healthcare is taken orally, typically as a tablet or capsule, with or without food as directed by the prescriber. Swallow the dosage form whole with water and avoid crushing or chewing unless specifically instructed.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic dysfunction, and neutropenia. Patients should seek immediate medical attention if they experience rash, difficulty breathing, jaundice, or unexplained fever while using the product.

Individuals with known hypersensitivity to noscapine or any excipients in the formulation should avoid the product. It is also contraindicated in patients taking multiple central cough suppressants or those with severe hepatic impairment without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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