Product image of Nosox Classic (Oxymetazoline Hydrochloride) supplied by GNH India

Nosox Classic

Active Ingredient:
Oxymetazoline Hydrochloride
Origin:
EU

Nosox Classic (Oxymetazoline Hydrochloride)

Oxymetazoline, the active ingredient in Nosox Classic, is an alpha‑adrenergic agonist presented as a nasal decongestant for nasal use. It relieves nasal congestion associated with the common cold, sinusitis and allergic rhinitis in adults and children.

GNH India supplies Nosox Classic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Nosox Classic, an alpha‑adrenergic nasal decongestant, is employed to alleviate congestion in several upper‑respiratory conditions.

  • Common cold: reduces swelling of nasal mucosa, improving airflow and easing breathing.
  • Sinusitis: diminishes mucosal edema, helping to clear blocked sinuses and relieve pressure.
  • Allergic rhinitis: lessens congestion caused by allergic inflammation, allowing better nasal patency.

How It Works

  • Oxymetazoline acts as a selective alpha‑1 adrenergic receptor agonist on the blood vessels of the nasal mucosa. Stimulation of these receptors causes vasoconstriction, which reduces vascular engorgement, decreases mucosal edema, and consequently opens the nasal passages, providing rapid relief of congestion.

Side Effects

Oxymetazoline may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing or mild headache.

Serious or Rare Side Effects

  • Rebound nasal congestion (rhinitis medicamentosa) with prolonged use.
  • Elevated blood pressure or tachycardia.
  • Severe allergic reaction such as angioedema or anaphylaxis.

Precautions & Warnings

Before using Nosox Classic, consider the following safety measures.

  • Do not exceed recommended frequency: limit to two doses within a 24‑hour period.
  • Avoid use in children under six years of age: safety has not been established.
  • Consult a healthcare professional if nasal symptoms persist longer than three days.
  • Use with caution in patients with hypertension or other cardiovascular disorders.
  • Avoid concomitant use with other sympathomimetic nasal products.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Oxymetazoline may interact with other medications; awareness of these interactions helps minimize risk.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other nasal decongestants: additive vasoconstrictive effects may increase local irritation.
  • Systemic sympathomimetic agents: may amplify cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: possible reduction in blood‑pressure‑lowering effect.
  • Beta‑blockers: may lead to increased heart rate.
  • Tricyclic antidepressants: potential for additive sympathomimetic activity.

Frequently Asked Questions

Nosox Classic is an over‑the‑counter nasal spray that contains oxymetazoline. It is used to temporarily relieve nasal congestion caused by the common cold, sinusitis, or allergic rhinitis by shrinking swollen blood vessels in the nasal passages.

Oxymetazoline is a selective alpha‑1 adrenergic agonist. When applied to the nasal mucosa it triggers vasoconstriction of the small blood vessels, which reduces swelling and edema, thereby opening the airway and easing breathing.

The exact dose is determined by the prescribing healthcare professional or the product label. For most OTC nasal sprays, the typical recommendation is one or two sprays per nostril, not exceeding two applications within a 24‑hour period, but users should follow the specific guidance provided with the product.

The pregnancy safety category for oxymetazoline is not definitively established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks with their physician before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Oxymetazoline generally provides faster and longer‑lasting relief than phenylephrine, another common OTC nasal decongestant. Both act as sympathomimetics, but oxymetazoline has a higher affinity for alpha‑1 receptors, which often translates into more pronounced vasoconstriction and a lower incidence of rebound congestion when used as directed.

Store the nasal spray at room temperature, away from excessive heat or moisture. Keep the container tightly closed when not in use, protect it from direct sunlight, and store it out of reach of children.

Nosox Classic is applied intranasally. The user should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the recommended number of sprays. The same procedure is repeated for the other nostril if required.

Serious risks include rebound nasal congestion (rhinitis medicamentosa) after prolonged use, significant increases in blood pressure, tachycardia, and rare allergic reactions such as angioedema or anaphylaxis. Users should discontinue the product and seek medical attention if any of these symptoms occur.

Individuals with known hypersensitivity to oxymetazoline or any component of the formulation should avoid the product. It is also contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) and in children younger than six years unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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