Product image of Nossin (Levocetirizine Dihydrochloride) supplied by GNH India

Nossin

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Nossin (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Nossin, is an antihistamine presented as an oral dosage form for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in adults and children.
GNH India supplies Nossin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurovitas Pharma Polska Sp. Z O.O

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Indications & Clinical Uses

Levocetirizine is used to manage allergic conditions by blocking peripheral H1 receptors.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery eyes.
  • Chronic idiopathic urticaria: alleviates hives and associated itching, improving patient comfort.

How It Works

  • Levocetirizine dihydrochloride acts as a selective antagonist of peripheral H1 histamine receptors. By binding to these receptors, it prevents histamine released during allergic reactions from triggering the typical inflammatory cascade, thereby diminishing vasodilation, increased vascular permeability, and sensory nerve stimulation that cause symptoms such as itching, swelling, and rhinorrhea.

Side Effects

Adverse reactions may occur with levocetirizine use.

Common Side Effects

  • Drowsiness: mild to moderate sedation, especially at treatment initiation.
  • Headache: transient, often resolves without intervention.
  • Dry mouth: reduced salivation leading to mild discomfort.
  • Fatigue: general tiredness not related to activity level.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, or tongue requiring urgent care.
  • Severe rash or Stevens‑Johnson syndrome: extensive skin involvement.
  • Anaphylaxis: rapid onset of systemic allergic reaction.
  • Thrombocytopenia: low platelet count, may present with bruising.
  • Hepatic injury: abnormal liver function tests, rarely symptomatic.

Precautions & Warnings

Before prescribing levocetirizine, consider patient‑specific factors and safety measures.

  • Pregnancy: consult a healthcare professional; risk‑benefit assessment is required.
  • Breastfeeding: use with caution; monitor infant for possible effects.
  • Renal impairment: dose adjustment may be necessary in reduced kidney function.
  • Hepatic impairment: monitor liver enzymes, especially in severe disease.
  • Driving and machinery: avoid operating heavy equipment if drowsiness occurs.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other substances that influence sedation or metabolism.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression, increasing drowsiness.
  • Other antihistamines: risk of excessive sedation and anticholinergic effects.
  • CNS depressants (e.g., benzodiazepines): may potentiate sedation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise levocetirizine plasma levels.
  • Theophylline: potential for increased theophylline concentrations, requiring monitoring.

Frequently Asked Questions

Nossin contains levocetirizine dihydrochloride and is prescribed to relieve symptoms of allergic rhinitis, such as sneezing, nasal congestion, and itchy eyes, as well as to control chronic idiopathic urticaria, reducing hives and itching. These indications reflect its role as a selective H1‑antihistamine for common allergic disorders.

Levocetirizine works by selectively blocking peripheral H1 histamine receptors. By preventing histamine from binding to these receptors, it stops the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation, thereby reducing the classic signs of an allergic reaction such as itching, swelling, and nasal discharge.

The appropriate dose of Nossin is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function, and clinical response. Dosage recommendations are individualized, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for levocetirizine in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing Nossin to pregnant or nursing mothers. If used, the patient should be monitored closely for any adverse effects on the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Nossin. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nossin (levocetirizine) is the active enantiomer of cetirizine, offering a more selective H1‑receptor blockade and often a lower incidence of sedation compared with first‑generation antihistamines. Compared with other second‑generation agents, its efficacy in allergic rhinitis and urticaria is comparable, while its safety profile remains favorable for most patients.

Nossin should be stored at room temperature, below 25 °C, in its original packaging. The container should be kept away from moisture, direct sunlight, and excessive heat to maintain product stability throughout its shelf life.

Nossin is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water and avoid crushing or chewing unless specifically instructed.

While generally well‑tolerated, Nossin can cause rare but serious adverse events such as angioedema, severe skin reactions (including Stevens‑Johnson syndrome), anaphylaxis, thrombocytopenia, and hepatic injury. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or signs of liver dysfunction.

Nossin is contraindicated in individuals with known hypersensitivity to levocetirizine, cetirizine, or any excipients in the formulation. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications that could increase sedation or plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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