Product image of Notaxo (Ebastine) supplied by GNH India

Notaxo

Active Ingredient:
Ebastine
Origin:
EU

Notaxo (Ebastine)

Ebastine, the active ingredient in Notaxo, is a second-generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.
GNH India supplies Notaxo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Ebastine acts on histamine‑mediated allergic pathways, providing relief in several allergic conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing and itching associated with seasonal or perennial allergies.
  • Chronic idiopathic urticaria: alleviates persistent hives and associated itching.
  • Allergic skin itching (pruritus): helps control itching caused by allergic skin reactions.

How It Works

  • Ebastine selectively blocks peripheral H1 receptors, preventing histamine from binding to these sites. By inhibiting the H1‑mediated cascade, it reduces vascular permeability, smooth‑muscle contraction, and sensory nerve activation that underlie allergic symptoms, without significant central nervous system penetration.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often reported.
  • Dry mouth: sensation of reduced salivation.
  • Drowsiness: occasional mild sedation.
  • Fatigue: feeling of reduced energy.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.
  • Anaphylaxis: rare systemic allergic reaction requiring immediate medical attention.

Precautions & Warnings

  • Before using Notaxo, consider the following precautions.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: weigh potential risks and benefits with a physician.
  • Renal impairment: dose may need adjustment in severe cases.
  • Elderly: monitor for increased sedation or dizziness.
  • Drug interactions: review all concomitant medications.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ebastine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Ketoconazole: may increase ebastine plasma concentrations.
  • Erythromycin: can raise ebastine levels, increasing side‑effect risk.
  • Ritonavir: may markedly elevate ebastine exposure.

Moderate Interactions (Monitor Closely)

  • Theophylline: potential for enhanced central effects.
  • CNS depressants: additive sedation may occur.
  • Alcohol: may increase drowsiness and dizziness.

Frequently Asked Questions

Notaxo contains ebastine, which is prescribed to relieve symptoms of allergic rhinitis, such as sneezing, runny nose and itching, as well as to manage chronic idiopathic urticaria, reducing hives and associated itching.

Ebastine works by selectively blocking peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to allergy symptoms like swelling, itching, and nasal congestion.

The appropriate dose of Notaxo is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and overall health status.

Safety data for ebastine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Notaxo.

To order Notaxo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antihistamines, ebastine (Notaxo) offers effective allergy relief with a lower likelihood of sedation because it does not readily cross the blood‑brain barrier. It is similar in efficacy to other second‑generation agents such as cetirizine or loratadine.

Notaxo should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.

Notaxo is taken orally, usually with a glass of water. It can be taken with or without food, as directed by the prescribing clinician.

Serious but rare risks include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or difficulty breathing.

Notaxo should be avoided in individuals with known hypersensitivity to ebastine or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, as well as those taking medications that strongly inhibit CYP3A4 without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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