Product image of Notus Antitusivo Y Expectorante (Dextromethorphan Hydrobromide, Guaifenesin) supplied by GNH India

Notus Antitusivo Y Expectorante

Active Ingredient:
Dextromethorphan Hydrobromide, Guaifenesin
Origin:
EU

Notus Antitusivo Y Expectorante (Dextromethorphan Hydrobromide, Guaifenesin)

Dextromethorphan Hydrobromide and Guaifenesin, the active ingredients in Notus Antitusivo Y Expectorante, are antitussive and expectorant agents presented as an oral formulation for oral use. They suppress the cough reflex and increase the volume of respiratory secretions, facilitating mucus clearance in adults and children with cough and chest congestion.

GNH India supplies Notus Antitusivo Y Expectorante as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide, adhering to EU quality standards and providing regulatory documentation for global distribution.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

Notus Antitusivo Y Expectorante combines an antitussive and an expectorant to address cough and mucus retention.

  • Cough: Reduces the frequency and intensity of dry or non‑productive cough.
  • Chest congestion: Helps loosen and thin bronchial secretions, easing congestion.
  • Mucus expectoration: Increases sputum volume and reduces viscosity to promote effective expectoration.

How It Works

  • Dextromethorphan acts as a sigma‑1 receptor agonist and NMDA receptor antagonist in the medullary cough centre, raising the threshold for cough initiation. Guaifenesin acts peripherally by increasing the water content of respiratory tract secretions, reducing their viscosity and enhancing mucociliary clearance, thereby facilitating expectoration. Together they provide symptomatic relief of cough and chest congestion.

Side Effects

Notus Antitusivo Y Expectorante may be associated with several adverse reactions, which are generally dose‑related and reversible.

Common Side Effects

  • Dizziness: mild sensation of light‑headedness.
  • Nausea: transient stomach upset.
  • Dry mouth: reduced salivation.
  • Somnolence: mild sleepiness.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Psychiatric effects: confusion, hallucinations, or agitation.
  • Respiratory depression: rare, especially with overdose or concomitant CNS depressants.

Precautions & Warnings

When considering Notus Antitusivo Y Expectorante, several safety considerations should be observed.

  • Age limitation: avoid use in children under 4 years unless directed by a physician.
  • CNS depressants: use caution with alcohol, opioids, or sedatives.
  • Pre‑existing conditions: assess for asthma, COPD, or chronic bronchitis before use.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Notus Antitusivo Y Expectorante can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome when combined with dextromethorphan.
  • Opioids: additive CNS depression and respiratory depression.
  • Sedating antihistamines: increased drowsiness.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: possible serotonergic effects.
  • Alcohol: may enhance sedation and dizziness.
  • Anticholinergic agents: may worsen dry mouth.

Frequently Asked Questions

Notus Antitusivo Y Expectorante is an over‑the‑counter oral product that combines dextromethorphan and guaifenesin to relieve cough, reduce chest congestion, and help clear mucus from the respiratory tract in adults and children.

Dextromethorphan acts centrally by binding to sigma‑1 receptors and antagonising NMDA receptors in the medullary cough centre, which raises the threshold for cough initiation and reduces the urge to cough.

The appropriate dose is determined by a qualified healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product label.

Safety data are limited. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before using this product to weigh potential benefits against possible risks.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with codeine‑containing cough syrups, Notus provides antitussive relief without opioid‑related dependence risk. It also adds an expectorant (guaifenesin), which many single‑ingredient dextromethorphan products lack, offering combined cough suppression and mucus clearance.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture, direct sunlight and extreme temperatures to maintain stability.

The medication is taken orally, usually as a liquid or tablet, as directed by the prescriber. It should be swallowed with a glass of water and not chewed unless the dosage form specifically requires it.

Serious risks include allergic reactions such as rash, swelling or anaphylaxis, serotonin syndrome when combined with certain antidepressants, and rare respiratory depression, especially if taken in excess or with other central nervous system depressants.

Individuals under 4 years of age (unless prescribed), patients taking monoamine oxidase inhibitors, those with known hypersensitivity to dextromethorphan or guaifenesin, and patients with severe respiratory disorders should avoid this product unless advised otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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