Nova Verde (Benzydamine Hydrochloride)

Benzydamine Hydrochloride is used topically in the oral cavity to reduce inflammation and pain in several mucosal conditions.

• Oral mucositis: reduces pain and inflammation, promoting comfort during chemotherapy or radiotherapy.
• Sore throat: alleviates throat pain and irritation associated with acute pharyngitis.
• Stomatitis: diminishes lesions and discomfort in the oral mucosa.
• Gingivitis: helps control inflammation and soreness of the gums.

• Benzydamine Hydrochloride acts locally on the oral mucosa by inhibiting the release of pro‑inflammatory cytokines such as IL‑1β and TNF‑α, stabilising cell membranes, and reducing the activity of phospholipase A2. This multi‑target action limits the synthesis of prostaglandins and leukotrienes, producing anti‑inflammatory, analgesic and mild anesthetic effects without significant systemic absorption. Additionally, it interferes with nerve signal transmission at peripheral sensory endings, contributing to its analgesic profile.

Benzydamine Hydrochloride is generally well tolerated, but local and systemic adverse reactions may occur.

Common Side Effects

• Taste alteration: transient metallic or bitter taste.
• Mild burning or stinging: sensation at application site.
• Nausea: occasional feeling of queasiness.
• Oral dryness: reduced salivation.

Serious or Rare Side Effects

• Allergic reactions: rash, urticaria, or angioedema.
• Severe mucosal irritation: ulceration or erosions.
• Anaphylaxis: rare systemic hypersensitivity requiring emergency care.

When using Benzydamine Hydrochloride, consider the following precautions to ensure safe and effective treatment.

• Hypersensitivity: avoid if known allergy to benzydamine or related compounds.
• Pregnancy: use only if clearly needed and prescribed by a healthcare professional.
• Prolonged use: limit duration to the period recommended by the prescriber to prevent mucosal irritation.
• Concomitant oral irritants: do not use simultaneously with other mouthwashes containing alcohol or strong antiseptics.
• Children: dosage and frequency should be determined by a pediatric specialist.
• Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Benzydamine Hydrochloride may interact with other medicines; awareness of these interactions helps minimise risk.

Major Interactions (Avoid)

• Other NSAIDs: concurrent use can increase risk of gastrointestinal irritation.
• Anticoagulants: may potentiate bleeding tendency when combined with systemic NSAIDs.

Moderate Interactions (Monitor Closely)

• Alcohol: may enhance local irritation or mucosal dryness.
• Local anesthetic mouthwashes: combined effect may increase numbness.
• Corticosteroid oral sprays: monitor for additive anti‑inflammatory effects.