Product image of Novalgin (Metamizole Sodium Monohydrate) supplied by GNH India

Novalgin

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novalgin (Metamizole Sodium Monohydrate)

Metamizole, the active ingredient in Novalgin, is a pyrazolone non‑opioid analgesic presented as an injection solution for intramuscular and intravenous use. It is employed to treat acute pain, post‑operative pain, fever, and colic or visceral pain in adult patients.

GNH India supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Opella Healthcare Czech S.R.O

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Indications & Clinical Uses

  • Novalgin (metamizole) is used for the management of pain and fever, acting within prostaglandin‑mediated pathways.
  • Acute pain: provides rapid analgesia for sudden severe pain.
  • Post‑operative pain: reduces discomfort after surgical procedures.
  • Fever: lowers elevated body temperature.
  • Colic and visceral pain: alleviates spasm‑related abdominal pain.

How It Works

  • Metamizole exerts its effect by non‑selectively inhibiting cyclooxygenase enzymes, which reduces prostaglandin synthesis. This leads to central analgesic activity and spasmolytic effects, contributing to pain relief and antipyretic action without opioid receptor involvement.

Side Effects

Novalgin may cause a range of adverse reactions.

Common Side Effects

  • Injection site pain: mild discomfort at the injection site.
  • Transient hypotension: temporary drop in blood pressure.
  • Nausea: feeling of sickness.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe allergic reactions (anaphylaxis): potentially life‑threatening hypersensitivity.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: serious skin reactions.
  • Blood dyscrasias: abnormal blood cell counts.

Precautions & Warnings

Novalgin requires careful clinical consideration before use.

  • Monitor blood counts: regular hematologic testing is advised.
  • Assess hypersensitivity: avoid in patients with known allergy to metamizole.
  • Caution in hepatic or renal impairment: adjust use based on organ function.
  • Use under medical supervision: only prescribed by qualified healthcare professionals.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Novalgin can interact with several medications.

Major Interactions (Avoid)

  • Myelosuppressive agents: increased risk of agranulocytosis.
  • Other NSAIDs: heightened potential for gastrointestinal bleeding.
  • ACE inhibitors: may enhance hypotensive effects.
  • Anticoagulants: increased bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible alteration of renal clearance.
  • Corticosteroids: may raise risk of gastric ulceration.
  • Alcohol: can augment dizziness and hypotension.

Frequently Asked Questions

Novalgin, containing metamizole, is indicated for the relief of acute pain, postoperative pain, fever, and colic or visceral pain. It is administered by injection and is commonly used in hospital settings for rapid symptom control in adult patients.

Metamizole acts by non‑selectively inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins. This inhibition provides central analgesic and spasmolytic effects, leading to pain relief and a reduction in fever without engaging opioid pathways.

The dose of Novalgin is determined by the prescribing clinician based on the patient’s condition, weight, and response. Healthcare professionals follow local guidelines and adjust the amount to achieve effective pain or fever control while monitoring safety.

Safety data for metamizole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Novalgin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Compared with traditional NSAIDs, metamizole offers strong analgesic and antipyretic effects with a lower incidence of gastric irritation but carries a risk of severe blood disorders. Unlike opioids, it does not cause respiratory depression, making it a useful alternative for certain acute pain scenarios.

Novalgin injection solution should be stored below 25 °C, in its original packaging, protected from light and moisture. Avoid freezing the product, and handle it using aseptic techniques to maintain sterility before administration.

Novalgin is given by intramuscular or intravenous injection under the supervision of a healthcare professional. The route and rate of administration are selected based on the clinical situation and patient tolerance.

The most serious adverse reactions include agranulocytosis, which can lead to severe infections, and severe allergic responses such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical attention is required if signs of these conditions appear.

Novalgin is contraindicated in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with existing severe blood dyscrasias, and those with a history of severe allergic reactions to the drug. It should also be avoided in patients where the risk of agranulocytosis outweighs the therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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