Product image of Novalgin (Metamizole Sodium Monohydrate) supplied by GNH India

Novalgin

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novalgin (Metamizole Sodium Monohydrate)

Metamizole, the active ingredient in Novalgin, is a pyrazolone analgesic presented as an oral formulation for systemic use. It is employed to relieve pain and reduce fever in adult patients.

GNH India supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Austria Gmbh

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Indications & Clinical Uses

Novalgin (metamizole) is used within the analgesic and antipyretic therapeutic area to manage several acute conditions.

  • Acute pain: provides rapid analgesic relief for short‑term severe pain.
  • Post‑operative pain: helps control discomfort following surgical procedures.
  • Fever: reduces elevated body temperature associated with infectious or inflammatory processes.

How It Works

  • Metamizole exerts its effect primarily by inhibiting cyclooxygenase activity, which leads to a decrease in prostaglandin synthesis. This reduction attenuates the sensitisation of nociceptors and lowers the hypothalamic set‑point for temperature regulation, thereby providing analgesic and antipyretic actions. The precise molecular pathways remain incompletely defined.

Side Effects

Metamizole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Agranulocytosis: potentially life‑threatening drop in white blood cells.
  • Severe allergic reactions: including anaphylaxis and Stevens‑Johnson syndrome.
  • Blood dyscrasias: such as thrombocytopenia or hemolytic anemia.

Precautions & Warnings

When using Novalgin, several safety considerations should be observed.

  • Monitor blood counts: regular hematologic testing is advised to detect agranulocytosis early.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Use caution in renal impairment: dose adjustment may be required.
  • Do not combine with other NSAIDs without medical supervision: increased risk of adverse effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Novalgin can interact with various medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Concurrent myelosuppressive agents: may cause severe bone‑marrow suppression.
  • Other pyrazolone derivatives: increased risk of agranulocytosis.
  • Drugs that lower blood pressure: may potentiate hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential enhancement of anticoagulant effect.
  • Methotrexate: may increase toxicity.
  • Lithium: possible rise in serum lithium concentrations.

Frequently Asked Questions

Novalgin contains the active ingredient metamizole and is used as an analgesic and antipyretic to treat moderate to severe pain and to lower fever in adult patients. It is commonly prescribed for acute pain, postoperative discomfort, and febrile conditions.

Metamizole works by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish the sensitisation of pain receptors and reset the hypothalamic temperature set‑point, providing both pain relief and fever reduction.

The appropriate dose of Novalgin is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal function. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of metamizole in pregnancy and lactation has not been definitively established. Healthcare providers usually weigh potential benefits against possible risks before prescribing it to pregnant or nursing women.

To request Novalgin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Novalgin (metamizole) belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct safety profile, notably a risk of agranulocytosis. Compared with paracetamol or ibuprofen, it may be chosen when those agents are ineffective or contraindicated, always under medical supervision.

Novalgin should be stored at ambient temperature, below 25 °C, in its original packaging. It must be kept away from moisture and direct sunlight to maintain product stability.

Novalgin is administered orally, typically as tablets or oral solution, and should be taken with or without food as directed by the prescriber. The exact method of administration depends on the formulation supplied.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, rash, or other adverse symptoms.

Novalgin should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, in patients with existing severe blood dyscrasias, and in those for whom the risk of agranulocytosis outweighs the therapeutic benefit. Clinical judgment is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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