Product image of Novalgin (Metamizole Sodium Monohydrate) supplied by GNH India

Novalgin

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novalgin (Metamizole Sodium Monohydrate)

Metamizole Sodium, the active ingredient in Novalgin, is a pyrazolone non‑opioid analgesic presented as an oral tablet for systemic use. It treats mild to moderate pain, postoperative pain, colic and fever in adults.

GNH India supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

A. Nattermann & Cie. Gmbh

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Indications & Clinical Uses

Novalgin is used for pain and fever management across several clinical situations.

  • Mild to moderate pain: provides analgesia for everyday pain conditions.
  • Post‑operative pain: helps control discomfort after surgical procedures.
  • Colic: relieves visceral pain associated with gastrointestinal spasm.
  • Fever: reduces elevated body temperature in febrile states.

How It Works

  • Metamizole Sodium inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis, and also modulates endogenous opioid pathways. This dual action contributes to its analgesic and antipyretic effects, although the precise molecular mechanisms are not fully defined.

Side Effects

Metamizole Sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Vomiting: occasional emesis.
  • Dizziness: transient light‑headedness.
  • Headache: mild to moderate intensity.
  • Rash: skin irritation or erythema.
  • Hypotension: occasional drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe allergic reactions: including anaphylaxis.
  • Stevens‑Johnson syndrome: rare skin disorder.
  • Blood dyscrasias: abnormal blood cell counts.
  • Hepatic injury: liver function impairment.
  • Renal failure: acute kidney injury in susceptible patients.

Precautions & Warnings

When prescribing Metamizole Sodium, clinicians should consider several safety aspects.

  • Renal impairment: use with caution and monitor kidney function.
  • Hepatic dysfunction: assess liver enzymes before initiation.
  • History of blood disorders: avoid in patients with prior agranulocytosis.
  • Concomitant pyrazolones: avoid combined use to reduce toxicity risk.
  • Pregnancy: limit to situations where benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metamizole Sodium can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Sulfonamide antibiotics: increased risk of agranulocytosis.
  • Cytotoxic chemotherapy agents: heightened bone‑marrow suppression.
  • Anticoagulants (e.g., warfarin): potential for enhanced bleeding.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • ACE inhibitors: possible additive hypotensive effect.
  • Diuretics: monitor electrolytes and renal function.

Frequently Asked Questions

Novalgin, containing Metamizole Sodium, is prescribed for mild to moderate pain, postoperative discomfort, colic associated with gastrointestinal spasm, and fever. It is used in adult patients when a non‑opioid analgesic is appropriate.

Metamizole Sodium blocks cyclooxygenase enzymes, lowering prostaglandin production, which reduces pain and fever. It also influences endogenous opioid pathways, enhancing analgesic effects, although the exact mechanisms are not completely understood.

The dosage of Novalgin is individualized by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. The prescriber determines the appropriate strength, frequency, and duration of therapy.

Safety data for Metamizole Sodium in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Novalgin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Novalgin belongs to the pyrazolone class, offering non‑opioid analgesia similar to other agents like dipyrone. Compared with NSAIDs, it may have a lower risk of gastrointestinal ulceration but carries a distinct risk of agranulocytosis, requiring careful monitoring.

Novalgin tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect them from moisture and direct sunlight to maintain stability and potency.

Novalgin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

The most serious adverse reactions include agranulocytosis, severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, and significant hepatic or renal injury. Prompt medical attention is required if any of these symptoms develop.

Novalgin is contraindicated in patients with known hypersensitivity to Metamizole or other pyrazolones, those with a history of agranulocytosis, severe liver or kidney disease, and individuals for whom safer alternatives are available.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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