Product image of Novalgin (Metamizole Sodium Monohydrate) supplied by GNH India

Novalgin

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Novalgin (Metamizole Sodium Monohydrate)

Metamizole, the active ingredient in Novalgin, is a pyrazolone analgesic presented as an oral formulation for oral use. It provides relief from acute pain, fever, postoperative discomfort and visceral colic, primarily in adult patients. The drug works by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis, and modulating central pain pathways, which contributes to its antipyretic and analgesic effects.

GNH India supplies Novalgin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Slovakia S.R.O.

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Indications & Clinical Uses

Novalgin (metamizole) is used to manage pain and fever across several clinical situations.

  • Acute pain: Reduces intensity of sudden, severe pain episodes.
  • Fever: Lowers elevated body temperature in febrile states.
  • Post‑operative pain: Provides analgesia after surgical procedures.
  • Colic and visceral pain: Alleviates spasm‑related abdominal discomfort.

How It Works

  • Metamizole exerts its analgesic and antipyretic actions primarily by inhibiting cyclooxygenase (COX) enzymes, which decreases the synthesis of prostaglandins involved in pain signaling and fever generation. Additionally, it influences central nervous system pathways, modulating nociceptive transmission at the spinal and supraspinal levels. This combined peripheral and central activity accounts for its effectiveness in treating various types of acute and visceral pain as well as febrile conditions.

Side Effects

Metamizole may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: Mild gastrointestinal upset.
  • Vomiting: Occasional emesis.
  • Dizziness: Transient light‑headedness.
  • Skin rash: Mild erythematous eruptions.
  • Hypotension: Temporary drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: Severe reduction in white blood cells.
  • Anaphylaxis: Life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: Severe skin and mucous membrane disorder.
  • Hepatotoxicity: Liver enzyme elevations or injury.

Precautions & Warnings

When prescribing or dispensing Novalgin, several safety considerations should be observed.

  • Indication assessment: Confirm that pain or fever warrants use of a pyrazolone analgesic.
  • Hematologic monitoring: Periodically check complete blood count, especially for agranulocytosis risk.
  • Renal function: Evaluate kidney status in patients with pre‑existing impairment.
  • Concomitant drugs: Review for potential interactions with anticoagulants or immunosuppressants.
  • Pregnancy and lactation: Use only if benefits outweigh potential risks, after professional evaluation.
  • Store at ambient temperature: Keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole can affect the activity of several other medicines; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): Enhanced myelosuppression.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: May potentiate hypotensive effects.
  • Diuretics: Possible additive blood pressure lowering.
  • Lithium: Risk of increased serum lithium levels.
  • Other NSAIDs: Combined gastrointestinal toxicity.

Frequently Asked Questions

Novalgin, containing the active ingredient metamizole, is indicated for the relief of acute pain, reduction of fever, management of postoperative discomfort, and treatment of colic or visceral pain. It is commonly prescribed for adult patients when rapid analgesic and antipyretic effects are required.

Metamizole works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production involved in pain and fever pathways. It also modulates central nervous system pain transmission, providing both peripheral and central analgesic effects that help control various types of acute and visceral pain.

The appropriate dose of Novalgin is determined by the prescribing clinician based on the patient’s age, weight, severity of pain or fever, and overall health status. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Safety of Novalgin in pregnancy or lactation has not been definitively established. It should only be used if the potential therapeutic benefit justifies the possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Novalgin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Novalgin (metamizole) belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct mechanism that includes central pain modulation. It may be preferred when NSAIDs are contraindicated, though it carries a unique risk profile, including rare blood‑cell disorders.

Novalgin should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Novalgin is administered orally, typically in tablet or liquid form, as directed by a healthcare professional. The medication should be taken with a full glass of water and may be taken with or without food, depending on the prescriber’s guidance.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, skin changes, or breathing difficulties, and seek immediate medical attention if these occur.

Novalgin should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis, severe liver or kidney impairment, and those taking medications that may interact dangerously, such as certain anticoagulants, without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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